Catalog No.
YHK75701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp346-Gln701
Predicted molecular weight
41.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NR19
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACS, AceCS1, ACSS2, Acyl-CoA synthetase short-chain family member 2, Propionate--CoA ligase, Acyl-activating enzyme, Acetate--CoA ligase, ACAS2, Acetyl-CoA synthetase, Acetyl-CoA synthetase 1, AceCS, Acetyl-coenzyme A synthetase, cytoplasmic
Hypoxia-Induced Up-Regulation of ACSS2 Drives the PI3K/AKT/mTOR Pathway Through HMGCS1 to Enhance the Proliferation and Stemness of Pancreatic Cancer Cells., PMID:40485521
Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets., PMID:40484921
The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription., PMID:40470746
ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice., PMID:40393969
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress., PMID:40331334
Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells., PMID:40244361
KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation., PMID:40131933
Dual inhibition of hepatic ACLY and ACSS2: A synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement., PMID:40127788
Ageing-associated gut dysbiosis deteriorates mouse cognition., PMID:39943805
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis., PMID:39932848
Discovery and mechanism of a highly selective, antifungal acetyl CoA synthetase inhibitor., PMID:39801522
Chaperone-mediated autophagy as a modulator of aging and longevity., PMID:39687864
Soybean isoflavone promotes milk yield and milk fat yield through the ERα-mediated Akt/mTOR pathway in dairy goats., PMID:39657106
Nutrient-driven histone code determines exhausted CD8+ T cell fates., PMID:39666821
Decreased voluntary alcohol intake and ventral striatal epigenetic and transcriptional remodeling in male Acss2 KO mice., PMID:39653249
Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer., PMID:39627427
ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis., PMID:39579354
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion., PMID:39561764
Developmental trajectories of atopic dermatitis with multiomics approaches in the infant gut: COCOA birth cohort., PMID:39547281
ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells., PMID:39484430
bta-miR-224 regulates milk fat metabolism by targeting FABP4 in bovine mammary epithelial cells., PMID:39481579
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones., PMID:39471817
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase., PMID:39471816
Integrated metagenomics and metabolomics analyses revealed biomarkers in β-casein A2A2-type cows., PMID:39411387
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer., PMID:39362518
Overexpression of PER2 Promotes De Novo Fatty Acid Synthesis, Fatty Acid Desaturation, and Triglyceride Accumulation in Bovine Mammary Epithelial Cells., PMID:39337271
Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production., PMID:39304063
The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis., PMID:39198451
ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses., PMID:39150482
ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma., PMID:38963759
HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma., PMID:38941296
miR-4443 Contained Extracellular Vesicles: A Factor for Endometriosis Progression by PI3K/AKT/ACSS2 Cascade in-vitro., PMID:38911502
FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis., PMID:38906101
ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway., PMID:38887280
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia., PMID:38851813
Identification of key markers for the stages of nonalcoholic fatty liver disease: An integrated bioinformatics analysis and experimental validation., PMID:38824040
Sodium Crotonate Alleviates Diabetic Kidney Disease Partially Via the Histone Crotonylation Pathway., PMID:38822951
Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells., PMID:38818373
Validation of mitochondrial biomarkers and immune dynamics in polycystic ovary syndrome., PMID:38661639
Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence., PMID:38615014
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation., PMID:38591127
Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway., PMID:38515158
Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro., PMID:38513237
Gehua Jiejiu Dizhi decoction ameliorates alcoholic fatty liver in mice by regulating lipid and bile acid metabolism and with exertion of antioxidant stress based on 4DLabel-free quantitative proteomic study., PMID:38504534
D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription., PMID:38460778
Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis., PMID:38429478
Protein Crotonylation Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells via the PI3K-AKT Pathway., PMID:38393294
USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma., PMID:38385089
Hyperacetylated histone H4 is a source of carbon contributing to lipid synthesis., PMID:38383863
Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA., PMID:38369012
For research use only. Not for human or drug use.
