Catalog No.
YHK75301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser781-Val914
Predicted molecular weight
17.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2K6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20
Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver., PMID:40463894
UCMSCs-derived exosomal SLIT2 alleviates ischemic stroke through the β-catenin/TCF4/USP20 signaling pathway., PMID:40272090
A comprehensive analysis of deubiquitinase USP20 on prognosis and immunity in pan-cancer., PMID:40270318
Chronic Exposure to Environmental Concentrations of Tetrabromobisphenol A Disrupts Insulin and Lipid Homeostasis in Diet-Induced Obese Mice., PMID:39998957
Cardiomyocyte Foxp1-Specific Deletion Promotes Post-injury Heart Regeneration via Targeting Usp20-HIF1ɑ-Hand1 Signaling Pathway., PMID:39899693
[Expression and clinical significance of USP20 in oral squamous cell carcinoma]., PMID:39719836
USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1., PMID:39674114
USP20 deletion promotes eccentric cardiac remodeling in response to pressure overload and increases mortality., PMID:39365672
siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice., PMID:39173829
A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions., PMID:38806474
USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy., PMID:38705724
Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder., PMID:38570483
A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis., PMID:38321831
ATR-dependent ubiquitin-specific protease 20 phosphorylation confers oxaliplatin and ferroptosis resistance., PMID:38124786
High-Carbohydrate Diet Consumption Poses a More Severe Liver Cholesterol Deposition than a High-Fat and High-Calorie Diet in Mice., PMID:37834148
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma., PMID:37598461
Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation., PMID:37311534
Plumbagin is a novel GPX4 protein degrader that induces apoptosis in hepatocellular carcinoma cells., PMID:37011699
LncRNA TINCR impairs the efficacy of immunotherapy against breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the STAT1-TINCR-USP20-PD-L1 axis., PMID:36725842
Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice., PMID:36636478
Ubiquitin-specific protease 20 in human disease: Emerging role and therapeutic implications., PMID:36423672
Advances in multi-omics study of biomarkers of glycolipid metabolism disorder., PMID:36382190
The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics., PMID:35508480
USP20 regulates the stability of EMT transcription factor SOX4 and influences colorectal cancer metastasis., PMID:35405623
Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma., PMID:35077391
The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein., PMID:35063767
USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal., PMID:34953448
A Panel of Engineered Ubiquitin Variants Targeting the Family of Domains Found in Ubiquitin Specific Proteases (DUSPs)., PMID:34666042
Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins., PMID:33792613
Expression, purification and characterization of the second DUSP domain of deubiquitinase USP20/VDU2., PMID:33529762
USP20 links feeding-induced cholesterol synthesis and energy expenditure., PMID:33420925
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis., PMID:33177714
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2., PMID:32943575
The Deubiquitinating Enzyme USP20 Regulates the TNFα-Induced NF-κB Signaling Pathway through Stabilization of p62., PMID:32354117
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA., PMID:31968013
Structural and functional studies of USP20 ZnF-UBP domain by NMR., PMID:31278784
USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA., PMID:30814308
The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling., PMID:30538132
USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis., PMID:30354204
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization., PMID:29867130
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation., PMID:29487085
Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells., PMID:28350092
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity., PMID:28167606
1H, 13C and 15N backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2., PMID:28091961
Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary., PMID:27156111
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA., PMID:27801882
Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination., PMID:27378762
Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation., PMID:26839314
Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20., PMID:25708858
Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress., PMID:25666616
For research use only. Not for human or drug use.
