Catalog No.
YHK75201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr30-Asp206
Predicted molecular weight
23.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BZM6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Retinoic acid early transcript 1I, UL16-binding protein 1, ALCAN-beta, N2DL-1, NKG2DL1, RAET1I, N2DL1, NKG2D ligand 1, ULBP1
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia., PMID:40440957
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory., PMID:40295473
Sesamin induces cell cycle arrest and upregulation of NKG2D ligands in MG‑63 cells and increases susceptibility to NK cell cytotoxicity., PMID:39991723
The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases., PMID:39866909
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment., PMID:39759895
B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies., PMID:39579618
UL16‑binding protein 1 is a significant prognostic and diagnostic marker for breast cancer., PMID:39492940
Elevated Circulatory Levels of UL16 Binding Protein 1 Positive Microparticles Are Associated With Acute Myocardial Infarction and its Severity., PMID:39477423
Temozolomide and the PARP Inhibitor Niraparib Enhance Expression of Natural Killer Group 2D Ligand ULBP1 and Gamma-Delta T Cell Cytotoxicity in Glioblastoma., PMID:39199623
Human esophageal cancer stem-like cells escape the cytotoxicity of natural killer cells via down-regulation of ULBP-1., PMID:39103915
Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis., PMID:38984872
The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation., PMID:38953028
Characterisation of RAET1E/ULBP4 exon 4 and 3' untranslated region genetic architecture reveals further diversity and allelic polymorphism., PMID:38575368
EIF2Ss, a Novel c-Myc-Correlated Gene Family, is Associated with Poor Prognosis and Immune Infiltration in Pancreatic Adenocarcinoma., PMID:38538250
Knockdown of the UL-16 binding protein 1 promotes osteoblast differentiation of human mesenchymal stem cells by activating the SMAD2/3 pathway., PMID:38481217
Porcine UL-16 Binding Protein 1 Is Not a Functional Ligand for the Human Natural Killer Cell Activating Receptor NKG2D., PMID:37998322
Identification of a potential signature to predict the risk of postmenopausal osteoporosis., PMID:37935322
Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)., PMID:37778428
Dynamics of Soluble Forms of the Immune Checkpoint Components PD-1/PD-L1/B7-H3, CD314/ULBP1, and HLA-G in Peripheral Blood of Melanoma Patients Receiving Blockers of Programmed Cell Death Protein PD-1., PMID:37773572
Targeting NKG2DL with Bispecific NKG2D-CD16 and NKG2D-CD3 Fusion Proteins on Triple-Negative Breast Cancer., PMID:37685962
Involvement of KLRK1 in immune infiltration of head and neck squamous cell carcinoma correlates with favorable prognosis., PMID:37565867
β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in BrafV600E-driven thyroid cancer cells., PMID:37483610
Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing., PMID:37298418
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients., PMID:36741391
Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate the Expression of Immunoregulatory UL16 Binding Protein 1., PMID:36179070
MMP-2 Inhibitor-Mediated Tumor Microenvironment Regulation Using a Sequentially Released Bio-Nanosystem for Enhanced Cancer Photo-Immunotherapy., PMID:36073504
Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells., PMID:35876924
Antioxidant nutrients can increase high-dose Methotrexate efficacy in 4T1 breast tumor Model: An experimental study on Vitamin E Succinate and Methyl-selenic acid., PMID:35803129
Levels of Soluble NKG2D Ligands and Cancer History in Patients Starting Hemodialysis., PMID:37674990
The metabolism of cells regulates their sensitivity to NK cells depending on p53 status., PMID:35217717
Immune ULBP1 is Elevated in Colon Adenocarcinoma and Predicts Prognosis., PMID:35211154
In vivo efficacy of decitabine as a natural killer cell-mediated immunotherapy against isocitrate dehydrogenase mutant gliomas., PMID:35104792
The Epstein-Barr Virus Oncogene EBNA1 Suppresses Natural Killer Cell Responses and Apoptosis Early after Infection of Peripheral B Cells., PMID:34781735
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition., PMID:34721381
Altered NK-cell compartment and dysfunctional NKG2D/NKG2D-ligand axis in patients with ataxia-telangiectasia., PMID:34298181
Downregulation of NKG2DLs by TGF-β in human lung cancer cells., PMID:34253166
Jinfukang inhibits lung cancer metastasis by upregulating CX3CL1 to recruit NK cells to kill CTCs., PMID:33933571
Tanshinone IIA enhances susceptibility of non-small cell lung cancer cells to NK cell-mediated lysis by up-regulating ULBP1 and DR5., PMID:33909909
Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma., PMID:33909599
Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study., PMID:33779082
The NKG2D ligand ULBP4 is not expressed by human monocytes., PMID:33556116
Expression of NKG2D ligands is downregulated by β-catenin signalling and associates with HCC aggressiveness., PMID:33484773
[Mechanism of Anti Apoptosis and Immune Evasion in Drug-Resistant Leukemia Cells Mediated by STAT3]., PMID:33283701
Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance., PMID:33279621
Assessment of NK Cell Activity Based on NK Cell-Specific Receptor Synergy in Peripheral Blood Mononuclear Cells and Whole Blood., PMID:33143099
Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome., PMID:33142138
Role of Sevoflurane on Natural Killer Group 2, Member D-Mediated Immune Response in Non-Small-Cell Lung Cancer: An In Vitro Study., PMID:33139690
Production of a novel bispecific protein ULBP1×CD19-scFv targeting the NKG2D receptor and CD19 to promote the activation of NK cells., PMID:33122138
Celecoxib upregulates ULBP-1 expression in lung cancer cells via the JNK/PI3K signaling pathway and increases susceptibility to natural killer cell cytotoxicity., PMID:33014157
[Effect of Chidamide on the Killing Acitivity of NK Cells Targeting K562 Cells and Its Related Mechanism In Vitro]., PMID:32798393
For research use only. Not for human or drug use.
