Catalog No.
YHJ66901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp523-His748
Predicted molecular weight
28.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRZ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PASG, Lymphoid-specific helicase, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, SMARCA6, HELLS, Proliferation-associated SNF2-like protein
HELLS controls mitochondrial dynamics and genome stability in liver cancer by collusion with MIEF1., PMID:40175344
CBX3 Downregulates HLTF to Activate PI3K/AKT Signaling Promoting Cholangiocarcinoma., PMID:39601498
CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes., PMID:39178260
The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS., PMID:39142653
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells., PMID:37709749
Lost in HELLS: Disentangling the mystery of SALNR existence in senescence cellular models., PMID:37252915
Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis., PMID:36194437
The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer., PMID:36012581
Diagnostic, Prognostic, and Immunological Roles of HELLS in Pan-Cancer: A Bioinformatics Analysis., PMID:35774795
Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis., PMID:35311456
Lymphoid-specific helicase in epigenetics, DNA repair and cancer., PMID:34493821
LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2., PMID:34223906
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation., PMID:34112784
The chromatin remodelling protein LSH/HELLS regulates the amount and distribution of DNA hydroxymethylation in the genome., PMID:33960278
The DNA-helicase HELLS drives ALK- ALCL proliferation by the transcriptional control of a cytokinesis-related program., PMID:33504766
Suppression of HELLS by miR-451a represses mTOR pathway to hinder aggressiveness of SCLC., PMID:33460027
HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3., PMID:33280236
A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association., PMID:33170271
CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats., PMID:33082427
PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment., PMID:33047671
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties., PMID:32994405
Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis., PMID:32900989
Chromatin regulators in retinoblastoma: Biological roles and therapeutic applications., PMID:32840881
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination., PMID:32727902
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis., PMID:32181600
The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK- anaplastic large cell lymphoma by regulating the DNA helicase HELLS., PMID:32123306
Pioneering meiotic recombination., PMID:32122967
Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression., PMID:32071286
HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots., PMID:32001511
The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation., PMID:31970665
The human HELLS chromatin remodelling protein promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin., PMID:31802118
DNA methylation in disease: Immunodeficiency, Centromeric instability, Facial anomalies syndrome., PMID:31724723
DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism., PMID:31594538
Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma., PMID:31541170
LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer., PMID:31253190
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression., PMID:31066149
Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas., PMID:30964110
Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC., PMID:30779712
HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma., PMID:30516846
Three Types of Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) Syndrome Identified by Whole-Exome Sequencing in Saudi Hypogammaglobulinemia Patients: Clinical, Molecular, and Cytogenetic Features., PMID:30511102
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome., PMID:30307408
Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric instability and Facial anomalies syndrome., PMID:30010917
Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state., PMID:29659838
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome., PMID:29339483
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability., PMID:29109788
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes., PMID:28900510
Expanding the mutation spectrum in ICF syndrome: Evidence for a gender bias in ICF2., PMID:28128455
TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma., PMID:28069330
Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas., PMID:28042322
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver., PMID:27473869
For research use only. Not for human or drug use.
