Catalog No.
YHK74301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys659-Thr801
Predicted molecular weight
18.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULT8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HECT-type E3 ubiquitin transferase HECTD1, E3 ubiquitin-protein ligase HECTD1, HECTD1, KIAA1131, EULIR, HECT domain-containing protein 1, E3 ligase for inhibin receptor
Hsa_circ_0002301 inhibits ferroptosis in gastric cancer by encoding the de novo protein HECTD1-463aa., PMID:40022084
Sequence variants in HECTD1 result in a variable neurodevelopmental disorder., PMID:39879987
α-Klotho prevents diabetic retinopathy by reversing the senescence of macrophages., PMID:39327553
Golgi Protein 73 Promotes Angiogenesis in Hepatocellular Carcinoma., PMID:39022745
Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis., PMID:38750549
Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects., PMID:38451291
Identification and Functional Analysis of Rare HECTD1 Missense Variants in Human Neural Tube Defects., PMID:38260607
Centriolin interacts with HectD1 in a cell cycle dependent manner., PMID:38115153
Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression., PMID:37993750
UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3., PMID:37760932
Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis., PMID:37186176
Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease., PMID:37165897
Proteomics analysis of prefrontal cortex of Alzheimer's disease patients revealed dysregulated proteins in the disease and novel proteins associated with amyloid-β pathology., PMID:37149819
Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis., PMID:36960892
Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function., PMID:36689659
Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia., PMID:36480964
CircUCK2 regulates HECTD1-mediated endothelial-mesenchymal transition inhibition by interacting with FUS and protects the blood-brain barrier in ischemic stroke., PMID:36326248
HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis., PMID:36121967
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis., PMID:35915203
Genome-wide identification and analysis of HECT E3 ubiquitin ligase gene family in Ruditapes philippinarum and their involvement in the response to heat stress and Vibrio anguillarum infection., PMID:35849989
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer., PMID:35832649
Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer., PMID:35530276
Global Gene Expression and Docking Profiling of COVID-19 Infection., PMID:35480316
Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7., PMID:35322810
STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo., PMID:35298637
Circular RNA HECTD1 knockdown inhibits transforming growth factor-beta/ small mothers against decapentaplegic (TGF-β/Smad) signaling to reduce hypertrophic scar fibrosis., PMID:35246019
Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1., PMID:35148069
Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis., PMID:34874325
Hsa_circ_0090002 regulates miR-186-5p/HECTD1 axis to mediate brain microvascular endothelial cell dysfunction., PMID:34801649
Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects., PMID:34445520
Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting Enterocyte Autophagy Via miR-182-5p/HuR Axis., PMID:34427642
The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1., PMID:33853758
Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis., PMID:33843447
Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis., PMID:33781347
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis., PMID:33711283
Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis., PMID:33561315
Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation., PMID:33435370
Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway., PMID:33148417
Identification of Candidate Biomarkers for Salt Sensitivity of Blood Pressure by Integrated Bioinformatics Analysis., PMID:33101363
CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism., PMID:32675746
Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway., PMID:32555320
HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition., PMID:32319576
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling., PMID:31799632
Integrated network analysis to explore the key mRNAs and lncRNAs in acute myocardial infarction., PMID:31698570
circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress., PMID:31607223
Hectd1 is essential for embryogenesis in mice., PMID:31301385
Reduced maternal vitamin A status increases the incidence of normal aortic arch variants., PMID:31299141
The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke., PMID:31257675
Identification of core genes and clinical roles in pregnancy-associated breast cancer based on integrated analysis of different microarray profile datasets., PMID:31171715
The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch., PMID:30578278
For research use only. Not for human or drug use.
