Catalog No.
YHK74201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly182-Lys372
Predicted molecular weight
22.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P0M6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Histone macroH2A2, H2AFY2, Core histone macro-H2A.2, mH2A2, MACROH2A2
Integrated Quantitative Proteomics and Phosphoproteomics Analysis Reveals the Dynamic Process of Buffalo (Bubalus bubalis) Spermatogenesis., PMID:39697112
Molecular characterization of histone gene in golden pompano (Trachinotus ovatus) and antimicrobial activity of its derived peptides., PMID:39209007
Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome., PMID:39189450
Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression., PMID:38251858
macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma., PMID:37244935
MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming., PMID:36823213
MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells., PMID:36459552
MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines., PMID:35732123
Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice., PMID:35590030
Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0., PMID:35072799
Exploring the Prognostic Value, Immune Implication and Biological Function of H2AFY Gene in Hepatocellular Carcinoma., PMID:34899687
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice., PMID:34469727
LSH catalyzes ATP-driven exchange of histone variants macroH2A1 and macroH2A2., PMID:34223906
Global Proteomic Profiling of Pediatric AML: A Pilot Study., PMID:34202615
LSH mediates gene repression through macroH2A deposition., PMID:33159050
An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus., PMID:32576231
H2AFY promoter deletion causes PITX1 endoactivation and Liebenberg syndrome., PMID:30711920
Transcription-associated histone pruning demarcates macroH2A chromatin domains., PMID:30291361
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms., PMID:30177554
H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia., PMID:29666008
A genome wide association study identifies new genes potentially associated with eyelid sagging., PMID:29654602
Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm., PMID:26658220
Epo-induced erythroid maturation is dependent on Plcγ1 signaling., PMID:25394487
Mice without macroH2A histone variants., PMID:25312643
U2AF1 mutations alter splice site recognition in hematological malignancies., PMID:25267526
A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters., PMID:25102063
Expression and functionality of histone H2A variants in cancer., PMID:25003966
Liebenberg syndrome is caused by a deletion upstream to the PITX1 gene resulting in transformation of the upper limbs to reflect lower limb characteristics., PMID:23587911
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency., PMID:23463008
Hunting biomarkers for Huntington's disease: H2AFY., PMID:22103616
Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse., PMID:21969577
X chromosome inactivation and differentiation occur readily in ES cells doubly-deficient for macroH2A1 and macroH2A2., PMID:21738686
The histone variant macroH2A is an epigenetic regulator of key developmental genes., PMID:19734898
Histone macroH2A isoforms predict the risk of lung cancer recurrence., PMID:19648962
Spatial distribution of histone isoforms on the bovine active and inactive X chromosomes., PMID:18418031
Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis., PMID:18053270
Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant., PMID:11331621
MACROH2A2, a new member of the MARCOH2A core histone family., PMID:11262398
For research use only. Not for human or drug use.
