Catalog No.
YHA29701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met95-Ala395
Predicted molecular weight
35.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14775
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Guanine nucleotide-binding protein subunit beta-5, GNB5, Gbeta5, Transducin beta chain 5
Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights., PMID:39957043
ITGB4/GNB5 axis promotes M2 macrophage reprogramming in NSCLC metastasis., PMID:39577216
Loss of CCL28 and CXCL17 Expression and Increase in CCR1 Expression May Be Related to Malignant Transformation of LGBLEL into Lymphoma., PMID:39451532
Murine Retina Outer Plexiform Layer Development and Transcriptome Analysis of Pre-Synapses in Photoreceptors., PMID:39337887
Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model., PMID:38373483
The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function., PMID:38354736
Gene Expression Profiling of Post Mortem Midbrain of Parkinson's Disease Patients and Healthy Controls., PMID:38255780
Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy., PMID:38166692
Inheritance of c.628-6G>A GNB5 hypomorphic allele uncovers another challenge in the pathogenic prediction of genomic variants., PMID:37994112
Comparisons of gene expression between peripheral blood mononuclear cells and bone tissue in osteoporosis., PMID:37335694
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors., PMID:37219953
Short course antibiotic treatment of Gram-negative bacteraemia (GNB5): a study protocol for a randomised controlled trial., PMID:37156588
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR., PMID:36996198
Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice., PMID:36831001
Gene mutations in comorbidity of epilepsy and arrhythmia., PMID:36376730
Predicting Novel Drug Candidates for Pancreatic Neuroendocrine Tumors via Gene Signature Comparison and Connectivity Mapping., PMID:35508682
Identification of Novel Noninvasive Diagnostics Biomarkers in the Parkinson's Diseases and Improving the Disease Classification Using Support Vector Machine., PMID:35342758
A transcriptomic analysis based on aberrant methylation levels revealed potential novel therapeutic targets for nasopharyngeal carcinoma., PMID:35282089
Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia., PMID:34894939
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5., PMID:34815401
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex., PMID:34793198
Identification of Cross-Pathway Connections via Protein-Protein Interactions Linked to Altered States of Metabolic Enzymes in Cervical Cancer., PMID:34790674
Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in MCCC1 and GNB5 Causing Overlapping Phenotypes., PMID:34573334
Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex., PMID:34112017
Second patient with GNB2-related neurodevelopmental disease: Further evidence for a gene-disease association., PMID:33971351
A New Mouse Model for Complete Congenital Stationary Night Blindness Due to Gpr179 Deficiency., PMID:33922602
[Protective function of electroacupuncture on young mouse model of Alzheimer's disease and proteomic study]., PMID:33798313
[Intellectual disorder and idiopathic sick sinus syndrome associated with GNB5 mutation: a case report]., PMID:33611908
Identification of Regeneration and Hub Genes and Pathways at Different Time Points after Spinal Cord Injury., PMID:33484404
The expression and prognostic value of GLYATL1 and its potential role in hepatocellular carcinoma., PMID:33457003
Genetic analyses of the endocannabinoid pathway in association with affective phenotypic variants., PMID:33421489
Identification of Crucial Genes and Diagnostic Value Analysis in Major Depressive Disorder Using Bioinformatics Analysis., PMID:33238838
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome., PMID:33172956
[Intellectual developmental disorder with cardiac arrhythmia syndrome in a family caused by GNB5 variation and literature review]., PMID:32987464
Genetic characterization and long-term management of severely affected siblings with intellectual developmental disorder with cardiac arrhythmia syndrome., PMID:32280589
The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion., PMID:32229584
IDDCA syndrome in a Chinese infant due to GNB5 biallelic mutations., PMID:32203251
Unique retinal signaling defect in GNB5-related disease., PMID:31720979
Exome reports A de novo GNB2 variant associated with global developmental delay, intellectual disability, and dysmorphic features., PMID:31698099
The epileptology of GNB5 encephalopathy., PMID:31631344
Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line., PMID:31479876
Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh)., PMID:31208990
iTRAQ-based quantitative proteomic analysis provides insights into strong broodiness in Muscovy duck (Cairina moschata) combined with metabolomics analysis., PMID:31152940
Modeling therapy resistance via the EGFR signaling pathway., PMID:30892828
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions., PMID:30864948
Systems analysis identifies potential target genes to overcome cetuximab resistance in colorectal cancer cells., PMID:30719834
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex., PMID:30540250
Differentially expressed gene (DEG) based protein-protein interaction (PPI) network identifies a spectrum of gene interactome, transcriptome and correlated miRNA in nondisjunction Down syndrome., PMID:30218739
Increased store-operated Ca2+ entry mediated by GNB5 and STIM1., PMID:29719456
For research use only. Not for human or drug use.
