Catalog No.
YHK74101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr45-Gln164
Predicted molecular weight
15.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NS18
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glutaredoxin-2, mitochondrial, GLRX2, GRX2
Investigating the causal relationships between mitochondrial proteins and dementia with Lewy bodies., PMID:40111912
The role of NRF2 function and regulation in atherosclerosis: an update., PMID:40025257
From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis., PMID:39314522
Ablating the glutaredoxin-2 (Glrx2) gene protects male mice against non-alcoholic fatty liver disease (NAFLD) by limiting oxidative distress., PMID:39278573
Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction., PMID:39117135
Machine-learning prediction of a novel diagnostic model using mitochondria-related genes for patients with bladder cancer., PMID:38654047
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway., PMID:38409085
Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients., PMID:38256132
Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase., PMID:37541331
The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function., PMID:37277068
Cryostress induces fragmentation and alters the abundance of sperm transcripts associated with fertilizing competence and reproductive processes in buffalo., PMID:37079096
Mitochondrial Glrx2 Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice., PMID:36139718
Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice., PMID:35290904
Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling., PMID:33581580
Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice., PMID:33224135
Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive., PMID:33002579
An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet., PMID:32993466
Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells., PMID:32694997
Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins., PMID:32651396
Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens., PMID:32148649
Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens., PMID:32106596
Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β., PMID:31382130
Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle., PMID:31317766
Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?, PMID:29540208
PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition., PMID:29385670
Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria., PMID:29274570
Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia., PMID:28618115
Systematic in vitro assessment of responses of roGFP2-based probes to physiologically relevant oxidant species., PMID:28242229
Protein S-glutathionylation alters superoxide/hydrogen peroxide emission from pyruvate dehydrogenase complex., PMID:28242228
Acid sphingomyelinase as target of Lycium Chinense: promising new action for cell health., PMID:27756324
Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase., PMID:26928132
Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice., PMID:25966442
Antioxidant supplementation during in vitro culture improves mitochondrial function and development of embryos from aged female mice., PMID:25739837
Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia., PMID:25735211
Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice., PMID:25362663
Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome., PMID:25004829
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons., PMID:24844147
Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions., PMID:24727547
Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal., PMID:24295294
Identification of a dithiol-disulfide switch in collapsin response mediator protein 2 (CRMP2) that is toggled in a model of neuronal differentiation., PMID:24133216
Glutaredoxin-2 is required to control proton leak through uncoupling protein-3., PMID:23335511
Disrupted redox homeostasis and aberrant redox gene expression in porcine oocytes contribute to decreased developmental competence., PMID:22811572
Glutaredoxin2 isoform b (Glrx2b) promotes RANKL-induced osteoclastogenesis through activation of the p38-MAPK signaling pathway., PMID:22449704
Vertebrate-specific glutaredoxin is essential for brain development., PMID:22139372
Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells., PMID:21983434
Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family., PMID:21837707
Glutaredoxin 2a, a mitochondrial isoform, plays a protective role in a human cell line under serum deprivation., PMID:21735102
Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver., PMID:21715529
Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange., PMID:21437321
The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity., PMID:21029046
For research use only. Not for human or drug use.
