Catalog No.
YHK74001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys347-Asn579
Predicted molecular weight
28.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NFG4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BHD skin lesion fibrofolliculoma protein, FLCN, Birt-Hogg-Dube syndrome protein, BHD, Folliculin
GPNMB Expression Identifies FLCN-Associated Eosinophilic Renal Tumors With Heterogeneous Clinicopathologic Spectrum and Gene Expression Profiles., PMID:40470587
Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication., PMID:40449101
Unveiling the Genetic Puzzle: Asymmetric Hypertrophy in a Heart Transplant Recipient Linked to Birt-Hogg-Dubé Syndrome., PMID:40332209
Folliculin (FLCN) in Thyroid Tumors: Incidence, Significance, and Role as a Driver Gene and Secondary Alteration., PMID:40277780
German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway., PMID:40232348
Antagonistic roles for MITF and TFE3 in melanoma plasticity., PMID:40138313
Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome cell models through transcriptomic and proteomic analysis., PMID:40133475
Limited Diagnostic Utility of PRDM10 Analysis in Birt-Hogg-Dubé Syndrome: Experience in 313 Consecutive Patients., PMID:40028672
A Case of Hybrid Cellular Neurothekeoma and Perineurioma With a Folliculin Gene Mutation., PMID:40015928
Clinical and genetic characteristics in two cases of Birt-Hogg-Dubé syndrome associated with papillary renal cell carcinoma and rare Folliculin (FLCN) variants., PMID:39893707
A case of pulmonary ALK-positive histiocytosis combined with Birt-Hogg-Dubé syndrome carrying an EML4::ALK gene fusion: a case report and literature review., PMID:39867882
A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress., PMID:39865126
Familial analysis: pulmonary Birt-Hogg-Dubé syndrome in two siblings., PMID:39842902
Induction of lysosome biogenesis is a novel function of the CGAS-STING1 pathway., PMID:39835593
YTHDF3-mediated FLCN/cPLA2 axis improves cardiac fibrosis via suppressing lysosomal function., PMID:39806064
Correlation of classic history, imaging and pathology with novel genetics in Birt-Hogg-Dubé syndrome., PMID:39730173
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance., PMID:39689715
Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation., PMID:39572689
GATA3 Expression in Solid Vimentin-Negative Eosinophilic Renal Epithelial Tumors-A Comprehensive Study of 48 Tumors., PMID:39523674
Cardiac rhabdomyoma: a rare feature of Birt-Hogg-Dubé syndrome., PMID:39461848
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation., PMID:39406246
Molecular chaperones: Guardians of tumor suppressor stability and function., PMID:39352796
Diagnosis of renal tumors in Birt-Hogg-Dube syndrome: Clinical presentation and risk factors in a single-center retrospective cohort., PMID:39354434
Pathogenic Germline Variants in Uveal Melanoma Driver and BAP1-Associated Genes in Finnish Patients with Uveal Melanoma., PMID:39344744
Clinical and genetic characteristics of 100 consecutive patients with Birt-Hogg-Dubé syndrome in Eastern Chinese region., PMID:39300538
Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways., PMID:39251783
A Confirmed Extrarenal Birt-Hogg-Dubé-Associated Oncocytic Neoplasm., PMID:39221876
ERN GENTURIS clinical practice guidelines for the diagnosis, surveillance and management of people with Birt-Hogg-Dubé syndrome., PMID:39085584
Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity., PMID:39026725
Two cases of Birt-Hogg-Dubé syndrome (Hornstein-Kinckenberg syndrome) with fibrofolliculoma and fibrous papules., PMID:39015969
Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis., PMID:38978568
A novel variant in the FLCN gene in a Chinese family with Birt-Hogg-Dubé syndrome., PMID:38963008
A Novel Mutation as a Rare Cause of Pneumothorax in a Soldier., PMID:38829725
A retrospective cohort study of genetic referral and diagnosis of Birt-Hogg-Dubé Syndrome in patients with Trichodiscoma and Fibrofolliculoma skin lesions., PMID:38822938
Birt-Hogg-Dubé syndrome with novel FLCN gene mutations and different clinical presentations: Case series., PMID:38676598
Skeletal muscle of young females under resistance exercise exhibits a unique innate immune cell infiltration profile compared to males and elderly individuals., PMID:38578562
Genetic Screening, Cancer Syndromes, and the Radiologist., PMID:38488500
The Prevalence and Radiologic Features of Renal Cancers Associated with FLCN, BAP1, SDH, and MET Germline Mutations., PMID:38456787
DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection., PMID:38430974
Structural insights into the ubiquitylation strategy of the oligomeric CRL2FEM1B E3 ubiquitin ligase., PMID:38360992
A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?, PMID:38249578
Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors., PMID:38242750
PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy., PMID:38183492
TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress., PMID:38168055
Recommendations on scuba diving in Birt-Hogg-Dubé syndrome., PMID:37991821
Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer., PMID:37772772
Oligodendrocyte development and myelin sheath formation are regulated by the antagonistic interaction between the Rag-Ragulator complex and TFEB., PMID:37767930
A Rare Case of Spontaneous Pneumothorax Recurrence 30 Years After Surgery in a Patient with Birt-Hogg-Dube Syndrome: Case Presentation and Short Review of the Literature., PMID:37711493
A Novel FLCN Variant in a Suspected Birt-Hogg-Dubè Syndrome Patient., PMID:37569793
For research use only. Not for human or drug use.
