Catalog No.
YHF17301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr245
Predicted molecular weight
28.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P56537
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation initiation factor 6, EIF3A, eIF-6, ITGB4BP, B(2)GCN homolog, B4 integrin interactor, CAB, p27(BBP), EIF6
eIF6: a promising therapeutic target for gastric carcinoma via PI3K/AKT pathway modulation., PMID:40170052
Whole genome transcriptomic profiling reveals distinct sex-specific responses to heat stroke., PMID:40066897
Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function., PMID:40045424
Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome., PMID:39964763
Biglycan fragment modulates TGF-β activity in intervertebral disc via an eIF6-coupled intracellular path., PMID:39951526
Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer., PMID:39940699
Sequestration of ribosomal subunits as inactive 80S by targeting eIF6 limits mitotic exit and cancer progression., PMID:39727167
Pirfenidone Downregulates eIF6, P311, and TGF-β Expression and Improves Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats: Evidence for Liver Regeneration., PMID:39681345
p38α-eIF6-Nsun2 axis promotes ILC3's rapid response to protect host from intestinal inflammation., PMID:39589554
The splicing factor SF3B1 is essential for proper alternative splicing and zygotic genome activation in early porcine embryos., PMID:39521214
Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia., PMID:39412990
eIF6 modulates skin wound healing by upregulating keratin 6B., PMID:39406496
Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis., PMID:39288622
eIF6 deficiency regulates gut microbiota, decreases systemic inflammation, and alleviates atherosclerosis., PMID:39225466
The Paradox of Ribosomal Insufficiency Coupled with Increased Cancer: Shifting the Perspective from the Cancer Cell to the Microenvironment., PMID:39001453
eIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle., PMID:38987443
The tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment., PMID:38644352
Rice OseIF6.1 encodes a eukaryotic translation initiation factor and is essential for the development of grain and anther., PMID:38576779
Turnip mosaic virus NIb weakens the function of eukaryotic translation initiation factor 6 facilitating viral infection in Nicotiana benthamiana., PMID:38388027
Effect of eIF6 on the development of silk glands and silk protein synthesis of the silkworm, Bombyx mori., PMID:38000606
Synergistic suppressive effects on triple-negative breast cancer by the combination of JTC-801 and sodium oxamate., PMID:37970352
Eukaryotic Initiation Factor 4E (eIF4E) as a Target of Anti-Psoriatic Treatment., PMID:37865179
Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis., PMID:37776372
N6-methyladenosine methylation regulatory pattern of pulmonary lymphoepithelioma-like carcinoma based on exosomal transcriptome analysis., PMID:37589421
Comprehensive analysis of resistance mechanisms to EGFR-TKIs and establishment and validation of prognostic model., PMID:37532906
Effect of RNA-binding proteins on osteogenic differentiation of bone marrow mesenchymal stem cells., PMID:37072640
Expression of Eukaryotic Translation Initiation Factors in the Urothelial Carcinoma of the Bladder., PMID:36974813
Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma., PMID:36902316
Site-specific labeling of SBDS to monitor interactions with the 60S ribosomal subunit., PMID:36781034
Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit., PMID:36651285
FCN3 inhibits the progression of hepatocellular carcinoma by suppressing SBDS-mediated blockade of the p53 pathway., PMID:36632465
Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn., PMID:36469534
Case Report: Heterozygous Germline Variant in EIF6 Additional to Biallelic SBDS Pathogenic Variants in a Patient With Ribosomopathy Shwachman-Diamond Syndrome., PMID:36035165
Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase., PMID:36009035
Diagnostic and prognostic utility of eIF6 in glioblastoma: a study based on TCGA and CGGA databases., PMID:35958479
Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study., PMID:35887068
eIF6 is potential diagnostic and prognostic biomarker that associated with 18F-FDG PET/CT features and immune signatures in esophageal carcinoma., PMID:35794622
Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer., PMID:35718769
eIF6 as a Promising Diagnostic and Prognostic Biomarker for Poorer Survival of Cutaneous Melanoma., PMID:35707354
The RNA binding protein OsLa influences grain and anther development in rice., PMID:35322500
eIF6 rebinding dynamically couples ribosome maturation and translation., PMID:35322020
The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function., PMID:35179490
Factoring in the force: A novel role for eIF6., PMID:35061888
Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells., PMID:35024764
Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway., PMID:34922580
Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)., PMID:34830804
Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time., PMID:34707094
Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families., PMID:34453201
circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway., PMID:34450253
Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function., PMID:34419449
For research use only. Not for human or drug use.
