Catalog No.
YHC21601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn12-Glu335
Predicted molecular weight
39.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06746
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA polymerase beta, POLB
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β., PMID:40031118
Pre-Steady-State Kinetic Studies of Nucleotide Incorporation into a Single-Nucleotide Gapped DNA Substrate Catalyzed by Human DNA Polymerase β., PMID:39931791
Mixture effects of arsenic and chromium on erythrocytic nuclear abnormalities and expression of DNA repair, tumor suppressor and apoptotic genes in liver of zebrafish., PMID:39826661
Influence of agarose in semi-IPN hydrogels for sustained Polymyxin B release., PMID:39673897
Effect of novel non-coding small RNA111 of Pseudomonas aeruginosa on bacterial virulence., PMID:39481694
Arsenic and Chromium Induced Toxicity on Zebrafish Kidney: Mixture Effects on Oxidative Stress and Involvement of Nrf2-Keap1-ARE, DNA Repair, and Intrinsic Apoptotic Pathways., PMID:39402722
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks., PMID:39243487
Genetic heterogeneity of engineered Escherichia coli Nissle 1917 strains during scale-up simulation., PMID:39111565
A duplexed high-throughput mass spectrometry assay for bifunctional POLB polymerase and lyase activity., PMID:39094983
The active components of Erzhi wan and their anti-Alzheimer's disease mechanisms determined by an integrative approach of network pharmacology, bioinformatics, molecular docking, and molecular dynamics simulation., PMID:39027618
SNP-Associated Substitutions of Amino Acid Residues in the dNTP Selection Subdomain Decrease Polβ Polymerase Activity., PMID:38785954
Modifying the Basicity of the dNTP Leaving Group Modulates Precatalytic Conformational Changes of DNA Polymerase β., PMID:38780930
Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway., PMID:38736258
Analysis of Cancer-Associated Mutations of POLB Using Machine Learning and Bioinformatics., PMID:38691429
Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: implication for immunotherapy., PMID:38680291
The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase β on Enzyme Activities., PMID:38673769
Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase β., PMID:38634780
Mouse models to explore the biological and organismic role of DNA polymerase beta., PMID:38619421
Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway., PMID:38366780
OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair., PMID:38363604
Comparison of in vitro synergy between polymyxin B or colistin in combination with 16 antimicrobial agents against multidrug-resistant Acinetobacter baumannii isolates., PMID:38350840
Effects of low‑power red laser and blue LED on mRNA levels from DNA repair genes in human breast cancer cells., PMID:38329547
Clinical relevance, mechanisms, and evolution of polymyxin B heteroresistance carbapenem-resistant Klebsiella pneumoniae: A genomic, retrospective cohort study., PMID:38295990
DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1., PMID:38245510
The complete mitochondrial genome of the mauve stinger jellyfish Pelagia noctiluca Forskål, 1775 (Cnidaria, Scyphozoa, Semaeostomeae) with phylogenetic analysis., PMID:38188449
Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway., PMID:38135179
DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC., PMID:37240218
The Activity of Natural Polymorphic Variants of Human DNA Polymerase β Having an Amino Acid Substitution in the Transferase Domain., PMID:37174699
Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy., PMID:37169279
Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility., PMID:36702010
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1-DNA interaction., PMID:36689867
The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation., PMID:35486639
Incorporation of 5',8-cyclo-2'deoxyadenosines by DNA repair polymerases via base excision repair., PMID:34871863
Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia., PMID:34757527
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis., PMID:34731617
Adintoviruses: a proposed animal-tropic family of midsize eukaryotic linear dsDNA (MELD) viruses., PMID:34646575
Virophages: association with human diseases and their predicted role as virus killers., PMID:34601577
Suppression of DNA Polymerase β Activity Is Synthetically Lethal in BRCA1-Deficient Cells., PMID:34240844
Protein Domain Specific Covalent Inhibition of Human DNA Polymerase β., PMID:34213836
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model., PMID:34186496
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis., PMID:34045188
Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor., PMID:34014094
Viruses infecting a warm water picoeukaryote shed light on spatial co-occurrence dynamics of marine viruses and their hosts., PMID:33972727
Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens., PMID:33746938
Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer., PMID:33673690
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities., PMID:33540226
A homology independent sequence replacement strategy in human cells using a CRISPR nuclease., PMID:33499763
A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β., PMID:33322249
Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution., PMID:33302546
DNA alternate polymerase PolB mediates inhibition of type III secretion in Pseudomonas aeruginosa., PMID:33276123
For research use only. Not for human or drug use.
