Catalog No.
YHJ91101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His45-Cys500
Predicted molecular weight
54.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6A2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cholesterol 24-hydroxylase, Cholesterol 24-monooxygenase, CH24H, CYP46A1, Cytochrome P450 46A1, CYP46, Cholesterol 24S-hydroxylase
Streptozotocin and L-Buthionine-Sulfoximine Decrease Neuron Membrane Lipid Packing and Alter Insulin Signaling., PMID:40439741
Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes., PMID:40235143
Design and identification of brain-penetrant, potent, and selective 1,3-oxazole-based cholesterol 24-hydroxylase (CH24H) inhibitors., PMID:40215592
Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions of Soticlestat as a Victim of CYP Induction and Inhibition, and as a Perpetrator of CYP and P-Glycoprotein Inhibition., PMID:40145722
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease., PMID:39964974
A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat., PMID:39963730
Therapeutic potential of mesenchymal stem cells on cholesterol homeostasis-associated genes in AD-like rats., PMID:39751793
Role of cholesterol in modulating brain hyperexcitability., PMID:39487852
Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis., PMID:39472682
KaiXinSan improves learning and memory impairment by regulating cholesterol homeostasis in mice overloaded with 27-OHC., PMID:39326716
Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke., PMID:39224978
Progress report on new medications for seizures and epilepsy: A summary of the 17th Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVII). II. Drugs in more advanced clinical development., PMID:39171993
The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression., PMID:39125645
Modulation of gene expression in immune-related organs by in ovo stimulation with probiotics and prophybiotics in broiler chickens., PMID:38987456
Modulation of Brain Cholesterol Metabolism through CYP46A1 Overexpression for Rett Syndrome., PMID:38931878
Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models., PMID:38897234
Inhibition of Glycyrrhiza Polysaccharide on Human Cytochrome P450 46A1 in vitro and in vivo: Implications in Treating Neurological Diseases., PMID:38797896
Construction and verification of an endoplasmic reticulum stress-related prognostic model for endometrial cancer based on WGCNA and machine learning algorithms., PMID:38725627
Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz., PMID:38719151
The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation., PMID:38592597
Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse., PMID:38540675
Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease., PMID:38513596
Aging and brain free cholesterol concentration on amyloid-β peptide accumulation in guinea pigs., PMID:38488691
7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite., PMID:38396919
Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer's pathology and dementia in the CFAS population-derived neuropathology cohort., PMID:38278219
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice., PMID:38266095
Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration., PMID:38142760
24S-Hydroxycholesterol in Neuropsychiatric Diseases: Schizophrenia, Autism Spectrum Disorder, and Bipolar Disorder., PMID:38036886
Oxysterols in Central and Peripheral Synaptic Communication., PMID:38036877
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis., PMID:37944529
Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats., PMID:37926403
Cytochrome P450 Family 46 Subfamily A Member 1 Promotes the Progression of Colorectal Cancer by Inducing Tumor Cell Proliferation and Angiogenesis., PMID:37909961
Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24-hydroxylase inhibitor soticlestat in healthy volunteers., PMID:37771051
Clinical Characterization of [18F]T-008, a Cholesterol 24-Hydroxylase PET Ligand: Dosimetry, Kinetic Modeling, Variability, and Soticlestat Occupancy., PMID:37770111
Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging., PMID:37619212
24-Hydroxycholesterol Moderates the Effects of Amyloid-β on Expression of HMG-CoA Reductase and ABCA1 Proteins in Mouse Astrocytes., PMID:37564436
Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer., PMID:37491786
Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum., PMID:37446179
Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer's Disease., PMID:37444065
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj-/- mice., PMID:37392222
Roles of bile acids signaling in neuromodulation under physiological and pathological conditions., PMID:37308953
The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice., PMID:37298459
The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis., PMID:37285742
Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3., PMID:37280310
Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults., PMID:37212649
Hepatic transcriptome analysis reveals that elovl5 deletion promotes PUFA biosynthesis and deposition., PMID:37080058
The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms., PMID:37062503
Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE)., PMID:37011526
The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet., PMID:36794015
Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro., PMID:36748817
For research use only. Not for human or drug use.
