Catalog No.
YHJ99902
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp475
Predicted molecular weight
55.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96KP4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Peptidase A, PEPA, CNDP2, Carnosine dipeptidase II, CN2, Epididymis secretory protein Li 13, Glutamate carboxypeptidase-like protein 1, CNDP dipeptidase 2, HEL-S-13, Cytosolic non-specific dipeptidase, CPGL
Dissecting the genetic association between abnormal sperm parameters and depression: a transcriptome-wide analysis of 157 participants., PMID:40263245
Comprehensive Proteomics and Machine Learning Analysis to Distinguish Follicular Adenoma and Follicular Thyroid Carcinoma from Indeterminate Thyroid Nodules., PMID:40205804
S146 and M148 within the mature chain domain of PSMB4 are crucial for degrading PRRSV nsp1α., PMID:40192860
Revealing the Microbial Origins of N-Lactoyl Amino Acids in Soy Sauce: Synthesis Conditions, Potential Enzymes, and Utilization Preference., PMID:39614824
Comparative Analysis of N-Lactoyl-phenylalanine and 3-Phenyllactic Acid Production in Lactic Acid Bacteria from Kimchi: Metabolic Insights and Influencing Factors., PMID:39606886
Plastic nanoparticles interfere with extracellular vesicle pathway in primary astrocytes., PMID:39437516
Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport., PMID:38517248
Characterization of the Effects of Low-Sodium Salt Substitution on Sensory Quality, Protein Oxidation, and Hydrolysis of Air-Dried Chicken Meat and Its Molecular Mechanisms Based on Tandem Mass Tagging-Labeled Quantitative Proteomics., PMID:38472852
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis., PMID:37621179
Functional Quality Characteristics of the Meat from a Dual-Purpose Poultry Crossbreed Suitable for Backyard Rearing in Comparison to Commercial Broilers., PMID:37444172
The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study., PMID:37291517
Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle., PMID:37171629
Distinct microRNA and protein profiles of extracellular vesicles secreted from myotubes from morbidly obese donors with type 2 diabetes in response to electrical pulse stimulation., PMID:37064893
Quantitative proteomic analysis of bronchoalveolar lavage fluids from patients with small cell lung cancers., PMID:36807835
Trans-10, cis-12 conjugated linoleic acid- and caloric restriction-mediated upregulation of CNDP2 expression in white adipose tissue in rodents, with implications in feeding and obesity., PMID:36641073
Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides., PMID:34324979
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics., PMID:31587987
CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway., PMID:31537175
Searching for prognostic biomarkers for small renal masses in the urinary proteome., PMID:31465112
A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism., PMID:30885138
Combined proteomic and miRNome analyses of mouse testis exposed to an endocrine disruptors chemicals mixture reveals altered toxicological pathways involved in male infertility., PMID:30698749
High-Intensity Interval Training Augments Muscle Carnosine in the Absence of Dietary Beta-alanine Intake., PMID:30334920
Development of Low-Molecular Weight Collagen Peptide Complex with Glycosaminoglycan Components., PMID:30225711
Responsiveness of Carnosine Homeostasis Genes in the Pancreas and Brain of Streptozotocin-Treated Mice Exposed to Dietary Carnosine., PMID:29890740
Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland., PMID:29764119
The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk., PMID:29402779
The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form., PMID:29056506
Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status., PMID:28871847
Twenty-four Weeks of β-Alanine Supplementation on Carnosine Content, Related Genes, and Exercise., PMID:28157726
Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry., PMID:26549037
Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes., PMID:26378572
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids., PMID:25964343
Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers., PMID:25225353
Biochemical, Biomedical and Metabolic Aspects of Imidazole-Containing Dipeptides with the Inherent Complexity to Neurodegenerative Diseases and Various States of Mental Well-Being: A Challenging Correction and Neurotherapeutic Pharmaceutical Biotechnology for Treating Cognitive Deficits, Depression and Intellectual Disabilities., PMID:25158972
Up-regulation of CNDP2 facilitates the proliferation of colon cancer., PMID:24885395
Quantitative proteomics approach to screening of potential diagnostic and therapeutic targets for laryngeal carcinoma., PMID:24587265
Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway., PMID:24395568
The influence of a single nucleotide polymorphism within CNDP1 on susceptibility to diabetic nephropathy in Japanese women with type 2 diabetes., PMID:23342076
Gene expression of carnosine-related enzymes and transporters in skeletal muscle., PMID:23124893
Interactive cellular proteins related to classical swine fever virus non-structure protein 2 by yeast two-hybrid analysis., PMID:23076522
[Carnosine, carnosinase and kidney diseases]., PMID:22706107
Purification and identification of two carnosine-cleaving enzymes, carnosine dipeptidase I and Xaa-methyl-His dipeptidase, from Japanese eel (Anguilla japonica)., PMID:22525515
Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease., PMID:22410244
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer., PMID:22128300
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes., PMID:21573905
Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA., PMID:20199107
Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases., PMID:19346245
Re: Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies., PMID:19033401
Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus., PMID:18790006
Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies., PMID:18753673
For research use only. Not for human or drug use.
