Catalog No.
YHF82202
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro292
Predicted molecular weight
35.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q00535
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell division protein kinase 5, Cyclin-dependent-like kinase 5, TPKII catalytic subunit, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, CDK5, CDKN5
Melatonin Enhances Aquaporin 4 and Alpha-Syntrophin Interaction by Inhibiting Cyclin-Dependent Kinase 5 Activity to Preserve Glymphatic Function in Neonatal Hypoxic-Ischemic Encephalopathy., PMID:40506855
GluN2B-Derived Small Interfering Peptide (GluN2B-Sip) Protects Against Sevoflurane-Induced Neurotoxicity in Developing Rats., PMID:40501436
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5., PMID:40476449
The Role of Kinases in Neurodegenerative Diseases: From Pathogenesis to Treatment., PMID:40464332
Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing., PMID:40425656
An in-silico study to identify potent phytochemicals for reducing neurotoxicity triggered by calpain and CDK5/p25 complex., PMID:40393181
Olaparib Triggers Mitochondrial Fission Through the CDK5/Drp-1 Signaling Pathway in Ovarian Cancer Cells., PMID:40384022
CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer., PMID:40370560
Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model., PMID:40358171
AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy., PMID:40320752
Enhancing the activity of γ-hydroxy lactone derivatives as innovative peroxisome proliferator-activated receptor γ non-agonists inhibiting cyclin-dependent kinase 5-mediated phosphorylation., PMID:40318479
CDK5 targets p21CIP1 to regulate thyroid cancer cell proliferation and malignancy in patients., PMID:40280108
Anticancer potential of novel benzothiazolyl piperidine-3-carboxamide derivatives as CDKs and VEGFR2 multi-target kinase inhibitors., PMID:40278942
Expression profiles of the Tau-associated genes GSk3β, CAPN1, and CDK5R1 in the brain cortex of aged female cynomolgus monkeys with cognitive impairment., PMID:40276183
Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs., PMID:40260078
ATG9B-4 accelerates the proliferation and migration of liver cancer cells in an ARNTL-CDK5 pathway-dependent manner: A case-control study., PMID:40258750
Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults., PMID:40254098
Oxytocin Anti-Apoptotic Potential Mediates Neuroprotection Against 3-Nitropropionic Acid-Induced Huntington's Disease-Like Pathophysiology in Rats: Involvement of Calpain-2/p25 Cdk5/MEF-2 Signaling Pathway., PMID:40252127
Unravelling the Proteinopathic Engagement of α-Synuclein, Tau, and Amyloid Beta in Parkinson's Disease: Mitochondrial Collapse as a Pivotal Driver of Neurodegeneration., PMID:40240583
A Cdk5 inhibitor restores cognitive function and alleviates type 2 diabetes in mice., PMID:40224020
CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract., PMID:40199395
Neuronal CDK5RAP3 deficiency leads to encephalo-dysplasia via upregulation of N-glycosylases and glycogen deposition., PMID:40188151
A Novel Variant c.149G>A in CDK5 Gene Causing Lissencephaly Type 7., PMID:40186457
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction., PMID:40178645
Identifying Alzheimer's disease genes in apolipoprotein E-/- mice brains with confirmed Porphyromonas gingivalis entry., PMID:40171450
Associations of maternal cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1) gene variants with adverse pregnancy outcome in Chinese women., PMID:40133860
SIRT1 Attenuates Neuropathic Pain via CDK5-Kalirin-7 Signaling Pathway in Type 2 Diabetic Rats., PMID:40133754
Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease., PMID:40111935
Talin1 Ser425 phosphorylation promotes colorectal cancer progression and metastasis., PMID:40104703
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
The influence of hypertensive disorders of pregnancy on the development of long-term postpartum type 2 diabetes mellitus., PMID:40074340
The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease., PMID:40071123
Phytoflavonoids as alternative therapeutic effect for melanoma: Integrative Network pharmacology, molecular dynamics and drug-likeness profiling for lead discovery., PMID:40056707
Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function., PMID:40032531
Clinical implications and molecular mechanism of long noncoding RNA LINC00518 and protein-coding genes in skin cutaneous melanoma by genome‑wide investigation., PMID:39987414
E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia-reperfusion injury., PMID:39968698
Eperisone Analogs, Rescuers of MiaB Defects As a Prokaryotic Homologue of CDKAL1, Suppress Blood Glucose Elevation in Rats., PMID:39967634
Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer., PMID:39959665
Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock., PMID:39937180
Novel dual-targeting PROTAC degraders of GSK-3β and CDK5: A promising approach for pancreatic cancer treatment., PMID:39892097
Involvement of CRMP2 Phosphorylation in Amyloid Beta-induced Tau Phosphorylation of Hippocampal Neurons in Alzheimer's Disease Mouse Model., PMID:39891817
Biosynthesis inhibition of miR-142-5p in a N6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling., PMID:39891095
Melatonin attenuates MPP+-induced autophagy via heat shock protein in the Parkinson's disease mouse model., PMID:39866567
Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection., PMID:39850902
CDK5: Insights into its roles in diseases., PMID:39836243
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation., PMID:39808222
Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos., PMID:39779142
Neuronal CD59 isoforms IRIS-1 and IRIS-2 as regulators of neurotransmitter release with implications for Alzheimer's disease., PMID:39773760
CDK5 interacts with MST2 and modulates the Hippo signalling pathway., PMID:39739588
Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment., PMID:39716791
For research use only. Not for human or drug use.
