Catalog No.
YHK73401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser67-Val314
Predicted molecular weight
30.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P287
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein TOK-1, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, BCCIP, TOK1
Combined targeting of TCF7L1/2, PTEN, CDK6, and BCCIP by microRNA miR-29c-3p is associated with reduced invasion and proliferation of endometriotic cells., PMID:40135061
Sequestration of ribosomal subunits as inactive 80S by targeting eIF6 limits mitotic exit and cancer progression., PMID:39727167
Medulloblastomas Initiated by Homologous Recombination Defects in Mice., PMID:39168365
The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis., PMID:38740325
Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma., PMID:38342812
Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes., PMID:38077434
Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes., PMID:37981907
Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress., PMID:35871033
Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer., PMID:35601016
The BRCA2 and CDKN1A-interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA., PMID:35592921
Identification of key gene contributing to vitiligo by immune infiltration., PMID:35535201
Overexpression of BCCIP predicts an unfavorable prognosis and promotes the proliferation and migration of lung adenocarcinoma., PMID:34297484
Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair., PMID:34043941
Structure of human BCCIP and implications for binding and modification of partner proteins., PMID:33452718
BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis., PMID:33245766
Requirement of Bccip for the Regeneration of Intestinal Progenitors., PMID:33039352
Chemoproteomic Profiling of an Ibrutinib Analogue Reveals its Unexpected Role in DNA Damage Repair., PMID:32979005
The crystal structure of protein-transporting chaperone BCP1 from Saccharomyces cerevisiae., PMID:32805410
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma., PMID:32736693
[Contact Sites of rDNA Clusters with FANK1 Gene Correspond to Repressed Chromatin]., PMID:32392195
Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice., PMID:32201259
The dichotomous effects of caffeine on homologous recombination in mammalian cells., PMID:32062581
YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1., PMID:31035388
The Penaeus stylirostris densovirus capsid protein interacts with the Litopenaeus vannamei BCCIP protein., PMID:30826413
BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells., PMID:29932276
Identification of microRNA signature in the progression of gestational trophoblastic disease., PMID:29367697
Roles of BCCIP deficiency in mammary tumorigenesis., PMID:29047390
BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction., PMID:28510697
Regulation of spindle integrity and mitotic fidelity by BCCIP., PMID:28394342
Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP., PMID:28386336
High Expression of BCCIP β Can Promote Proliferation of Esophageal Squamous Cell Carcinoma., PMID:27995408
Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation., PMID:27832471
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing., PMID:27694622
Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells., PMID:27535137
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53., PMID:25995247
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53., PMID:25487856
The beta-isoform of the BRCA2 and CDKN1A(p21)-interacting protein (BCCIP) stabilizes nuclear RPL23/uL14., PMID:25150171
BCCIP suppresses tumor initiation but is required for tumor progression., PMID:24145349
Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues., PMID:24101097
Mutation analysis of the BCCIP gene for breast cancer susceptibility in breast/ovarian cancer families., PMID:23911796
Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer., PMID:23729402
17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration., PMID:22691413
Differential gene expression in rainbow trout (Oncorhynchus mykiss) liver and ovary after exposure to zearalenone., PMID:22683937
Requirement of mouse BCCIP for neural development and progenitor proliferation., PMID:22292003
Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes., PMID:21966279
Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways., PMID:20334671
The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair., PMID:19808958
BCCIP is required for the nuclear localization of the p21 protein., PMID:19713748
Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas., PMID:19653894
Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin., PMID:19530225
For research use only. Not for human or drug use.
