Catalog No.
YHH18501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln154-Asn230
Predicted molecular weight
21.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15758
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Baboon M7 virus receptor, SLC1A5, Solute carrier family 1 member 5, ASCT2, RDR, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, ATB(0), Neutral amino acid transporter B(0), M7V1, RDRC
Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress., PMID:40505348
Mechanism of SLC1A5 Regulation of Glutamine Metabolism to Promote Ferroptosis Sensitivity in Endometriosis., PMID:40464516
Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells., PMID:40448242
Tamoxifen regulates ferroptosis of hepatocytes by targeting SLC1A5 to activate hepatic stellate cells and liver fibrosis., PMID:40436235
Immunosuppressive Effects of Multiple Myeloma-Derived Extracellular Vesicles Through T Cell Exhaustion., PMID:40344445
Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer., PMID:40312304
Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling., PMID:40258522
Repeated administration of L-alanine to mice reduces behavioural despair and increases hippocampal mammalian target of rapamycin signalling: Analysis of gender and metabolic effects., PMID:40242990
An excitatory amino acid transporter 1 acts as a novel glutamine transporter and immune modulator in the oyster Crassostrea gigas., PMID:40228773
Inhibition of GLS1 and ASCT2 Synergistically Enhances the Anticancer Effects in Pancreatic Cancer Cells., PMID:40223274
The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis., PMID:40158101
Exploring the Molecular Intersection of Posterior Ocular Tuberculosis: Mycobacterium tuberculosis Proteins, Ocular Autoimmunity, and Immune Receptor Interactions., PMID:40151358
Altered structural and transporter-related gene expression patterns in the placenta play a role in fetal demise during Porcine reproductive and respiratory syndrome virus infection., PMID:40119254
Long-term leucine supplementation increases body weight in goats by controlling appetite and muscle protein synthesis under protein-restricted conditions., PMID:40034461
[SLC1A5 overexpression accelerates progression of hepatocellular carcinoma by promoting M2 polarization of macrophages]., PMID:40031971
IL17A/F secreted by ASCT2-overexpression ovarian cancer cells contributes to immune escape through the suppression of natural killer (NK) cells cytotoxicity by the activation of c-JUN/ PTGS2 pathway., PMID:39954656
Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells., PMID:39909124
Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy., PMID:39875895
SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer., PMID:39843491
Establishment and characterization of a new mouse gastric carcinoma cell line, MCC., PMID:39800685
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma., PMID:39798576
RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters., PMID:39757767
Identification of potential biomarkers from amino acid transporter in the activation of hepatic stellate cells via bioinformatics., PMID:39698464
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets., PMID:39659992
KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5-Mediated Tryptophan Metabolism., PMID:39648156
Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma., PMID:39639273
Alternative polyadenylation landscape of longissimus dorsi muscle with high and low intramuscular fat content in cattle., PMID:39565284
Is ASCT2 a Suitable Vector for the Selective Delivery of Anticancer Drugs? Modification of Glutamine at Either the Carboxylate or the Side Chain Hinders Binding and Transport., PMID:39562323
Ginsenoside compound K restrains hepatic fibrotic response by dual-inhibition of GLS1 and LDHA., PMID:39561660
Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer., PMID:39519124
DON encapsulated carbon dot-vesicle conjugate in therapeutic intervention of lung adenocarcinoma by dual targeting of CD44 and SLC1A5., PMID:39513401
Integrated stress response-upregulated mitochondrial SLC1A5var enhances glucose dependency in human breast cancer cells in vitro., PMID:39505107
LINC01134 Directly Binds and Regulates SLC1A5 Stability to Promotes Colorectal Cancer Progression., PMID:39440055
Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta., PMID:39432789
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance., PMID:39431017
Methionine supply during mid-gestation modulates the bovine placental mTOR pathway, nutrient transporters, and offspring birth weight in a sex-specific manner., PMID:39390894
Differential gene expression in neonatal calf muscle tissues from Hanwoo cows overfed during mid to late pregnancy period., PMID:39375502
Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology., PMID:39344414
Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of Ewing sarcoma., PMID:39307979
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma., PMID:39236712
Methodological Approaches for Increasing the Retroviral Transduction Efficiency of Primary NK Cells., PMID:39136515
Integrated machine learning screened glutamine metabolism-associated biomarker SLC1A5 to predict immunotherapy response in hepatocellular carcinoma., PMID:39096658
Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2., PMID:39095408
Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer., PMID:39079386
Co-Expression Network Analysis and Molecular Docking Demonstrate That Diosgenin Inhibits Gastric Cancer Progression via SLC1A5/mTORC1 Pathway., PMID:39071813
ASCT2 is a major contributor to serine uptake in cancer cells., PMID:39068660
Reprogramming of Glutamine Amino Acid Transporters Expression and Prognostic Significance in Hepatocellular Carcinoma., PMID:39062801
HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration., PMID:39032683
Glutamine metabolic competition drives immunosuppressive reprogramming of intratumour GPR109A+ myeloid cells to promote liver cancer progression., PMID:38981667
UBE2C-induced crosstalk between mono- and polyubiquitination of SNAT2 promotes lymphatic metastasis in bladder cancer., PMID:38949026
For research use only. Not for human or drug use.
