Catalog No.
YHA86401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly41-Gly340
Predicted molecular weight
37.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60285
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Omphalocele kinase 1, ARK5, NUAK family SNF1-like kinase 1, OMPHK1, AMPK-related protein kinase 5, NUAK1, KIAA0537
Osthole Induces Hepatic Stellate Cell Ferroptosis to Alleviate Liver Fibrosis by Inhibiting the Y-Box Binding Protein 1-Wnt/β-Catenin Axis Through Downregulating Myocyte Enhancer Factor 2A., PMID:40317895
The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta., PMID:40228123
Functional characterization of key protein biomarkers in spontaneous intracerebral hemorrhage pathogenesis: Structure and function of NUAK1 protein and ERO1L protein macromolecules., PMID:40203915
Development of the Pyrido[2,3-d]pyrimidin-7(8H)-one Scaffold toward Potent and Selective NUAK1 Inhibitors., PMID:39967649
NUAKs facilitate mTOR-mediated NSCLC proliferation and metastasis by modulating glucose metabolism and inhibiting p53 activity., PMID:39965261
NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma., PMID:39901136
Overexpression of Drosophila NUAK or Constitutively-Active Formin-Like Promotes the Formation of Aberrant Myofibrils., PMID:39876757
Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity., PMID:39824180
Prognostic significance of NUAK1 and its association with immune infiltration in stomach adenocarcinoma., PMID:39692916
Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies., PMID:39588908
NUAKs promote mTOR/c-Myc-induced glucose and glutamine reprogramming for cell growth and metastasis in breast cancer cells., PMID:39270807
Insight in the (Phospho)proteome of Vascular Smooth Muscle Cells Derived From Patients With Abdominal Aortic Aneurysm Reveals Novel Disease Mechanisms., PMID:39206541
NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non-Small Cell Lung Carcinoma., PMID:39159134
1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes., PMID:39141942
NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer., PMID:38996065
NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation., PMID:38967580
NUAK: never underestimate a kinase., PMID:38939918
The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions., PMID:38514619
Genetic architecture of the structural connectome., PMID:38438384
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003., PMID:38175261
Cancer susceptibility 18 positively regulates NUAK Family Kinase 1 expression to promote migration and invasion via sponging of miR-5586-5p in cervical cancer cells., PMID:38131232
Ovarian cancer relies on the PDGFRβ-fibronectin axis for tumorsphere formation and metastatic spread., PMID:38010623
Evaluation of ARK5 and SIRT3 expression in renal cell carcinoma and their clinical significance., PMID:37996927
Identification of key genes in spontaneous cerebral hemorrhage and prevention of disease damage: LASSO and SVM regression., PMID:37473923
The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders., PMID:37236919
NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4., PMID:36975767
AMPK-like proteins and their function in female reproduction and gynecologic cancer., PMID:36858738
Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer., PMID:36856946
A prediction model for prognosis of gastric adenocarcinoma based on six metabolism-related genes., PMID:36852096
DKK1 promotes NUAK1 transcriptional expression through the activation Akt in hepatocellular carcinoma., PMID:36480792
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids., PMID:36435939
Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p., PMID:36255069
Nuak kinase signaling in development and disease of the central nervous system., PMID:36122883
miR-622 Counteracts the NUAK1-Induced Gastric Cancer Cell Proliferation and the Antioxidative Stress., PMID:35872695
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities., PMID:35817555
Discovery of a novel NUAK1 inhibitor against pancreatic cancer., PMID:35691157
NUAK1 promotes kidney fibrosis., PMID:35484398
NUAK1 inhibition prevents fibrosis., PMID:35388207
NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling., PMID:35320001
Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer., PMID:35194062
NUAK Kinases: Brain-Ovary Axis., PMID:34685740
The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer., PMID:34504167
Verification of immunology-related genetic associations in BPD supports ABCA3 and five other genes., PMID:34465876
Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling., PMID:34326372
NUAK1 and NUAK2 Fine-Tune TGF-β Signaling., PMID:34282782
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965., PMID:34259310
LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5., PMID:34097192
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription., PMID:34087181
Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment., PMID:34084284
High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching., PMID:33854138
For research use only. Not for human or drug use.
