Catalog No.
YHC96601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg217-Ala640
Predicted molecular weight
49.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13196
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALASH, 5-aminolevulinic acid synthase 1, ALAS1, Delta-ALA synthase 1, ALAS3, ALAS-H, Delta-aminolevulinate synthase 1, 5-aminolevulinate synthase, nonspecific, mitochondrial
Integrated Analysis of Single-Cell and Bulk RNA Data Reveals Complexity and Significance of the Melanoma Interactome., PMID:39796775
5-Aminolevulinic Acid (5-ALA) Plays an Important Role in the Function of Innate Immune Cells., PMID:39702622
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing., PMID:39700288
Givosiran: a targeted treatment for acute intermittent porphyria., PMID:39644007
Heme deficiency in skeletal muscle exacerbates sarcopenia and impairs autophagy by reducing AMPK signaling., PMID:39333763
RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation., PMID:38948092
Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy., PMID:38888238
Case-based discussion of the acute hepatic porphyrias: Updates on pathogenesis, diagnosis and management., PMID:38618923
Berberine as a potential enhancer for 5-ALA-mediated fluorescence in glioblastoma: increasing detectability of infiltrating glioma stem cells to optimize 5-ALA-guided surgery., PMID:38457785
Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle., PMID:38412099
FLVCR1a Controls Cellular Cholesterol Levels through the Regulation of Heme Biosynthesis and Tricarboxylic Acid Cycle Flux in Endothelial Cells., PMID:38397386
Heme Biosynthesis is Crucial for Cell Survival and Mitochondrial OXPHOS after X Irradiation., PMID:37988802
Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran., PMID:37871778
Active Estrogen-Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells., PMID:37509133
Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells., PMID:37062833
Antagonism of ALAS1 by the Measles Virus V protein contributes to degradation of the mitochondrial network and promotes interferon response., PMID:36802406
Identification of novel biomarkers involved in doxorubicin-induced acute and chronic cardiotoxicity, respectively, by integrated bioinformatics., PMID:36712272
ALAS1 associated with goat kidding number trait was regulated by the transcription factor ASCL2 to affect granulosa cell proliferation., PMID:36632647
Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library., PMID:35969671
Spotlight on Givosiran as a Treatment Option for Adults with Acute Hepatic Porphyria: Design, Development, and Place in Therapy., PMID:35734365
The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury., PMID:35470464
Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution., PMID:35327450
Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats., PMID:35294485
Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy., PMID:35249268
Complex response to physiological and drug-induced hepatic heme demand in monoallelic ALAS1 mice., PMID:34900592
Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX., PMID:34704252
Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma., PMID:34635508
Inactivation of PDH can Reduce Anaplastic Thyroid Cancer Cells' Sensitivity to Artemisinin., PMID:34515013
A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver., PMID:34510420
[New therapeutic option for acute hepatic porphyrias]., PMID:34344029
The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover., PMID:34280433
Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity., PMID:34249128
Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia., PMID:34176941
Novel vectors and approaches for gene therapy in liver diseases., PMID:34159305
The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation., PMID:34133926
Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine-Conjugated RNA Interference Therapeutic., PMID:33941543
Givosiran: A Review in Acute Hepatic Porphyria., PMID:33871817
Effects of Doxorubicin on Heme Biosynthesis and Metabolism in Cardiomyocyte., PMID:33656082
Mitochondrial transcription factor A induces the declined mitochondrial biogenesis correlative with depigmentation of brown eggshell in aged laying hens., PMID:33518349
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin., PMID:33199206
Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro., PMID:32270771
Givosiran: First Approval., PMID:32034693
Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran., PMID:31792921
Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI., PMID:31754094
Hypothesis: Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias., PMID:31443750
Genome-Wide Scan Identifies Selection Signatures in Chinese Wagyu Cattle Using a High-Density SNP Array., PMID:31151238
Current and innovative emerging therapies for porphyrias with hepatic involvement., PMID:31102718
A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1., PMID:31086989
Impaired heme metabolism in schizophrenia-derived cell lines and in a rat model of the disorder: Possible involvement of mitochondrial complex I., PMID:30948194
Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells., PMID:30902795
For research use only. Not for human or drug use.
