Catalog No.
YHB46501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly276-Lys417
Predicted molecular weight
18.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94874
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Multiple alpha-helix protein located at ER, KIAA0776, Regulator of C53/LZAP and DDRGK1, Novel LZAP-binding protein, E3 UFM1-protein ligase 1, NLBP, RCAD, MAXER, E3 UFM1-protein transferase 1, UFL1
Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis., PMID:40502001
Proximity biotinylation at the host- Shigella interface reveals UFMylation as an antibacterial pathway., PMID:40501833
UFMylation promotes orthoflavivirus infectious particle production., PMID:40459261
Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis., PMID:40419786
UFMylation orchestrates spatiotemporal coordination of RQC at the ER., PMID:40315331
UFMylation Modulates OFIP Stability and Centrosomal Localization., PMID:40059580
UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation., PMID:39985286
Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease., PMID:39858578
The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy., PMID:39842454
UFMylation promotes orthoflavivirus infectious particle production., PMID:39829754
Ufmylation: a potential modification for neurological diseases., PMID:39757643
A novel nuclear RNA HSD52 scaffolding NONO/SFPQ complex modulates DNA damage repair to facilitate temozolomide resistance., PMID:39673809
Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BmBIP., PMID:39551318
Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling., PMID:39405202
Protein UFMylation regulates early events during ribosomal DNA-damage response., PMID:39277864
Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics., PMID:39084678
Bombyx mori UFL1 facilitates BmNPV proliferation by regulating host cell apoptosis through PERK., PMID:38976652
The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER., PMID:38905340
UFL1 regulates cellular homeostasis by targeting endoplasmic reticulum and mitochondria in NEFA-stimulated bovine mammary epithelial cells via the IRE1α/XBP1 pathway., PMID:38821134
VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy., PMID:38762759
PTIP UFMylation promotes replication fork degradation in BRCA1-deficient cells., PMID:38657865
PARP1 UFMylation ensures the stability of stalled replication forks., PMID:38657044
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells., PMID:38649452
Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production., PMID:38477617
The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons., PMID:38383789
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER., PMID:38383785
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity., PMID:38377992
DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis., PMID:38233375
Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation., PMID:37988244
Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice., PMID:37980507
UFMylation: a ubiquitin-like modification., PMID:37945409
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis., PMID:37795761
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control., PMID:37595036
Identifying causal genes for migraine by integrating the proteome and transcriptome., PMID:37592229
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation., PMID:37311461
Proximity Proteomics and Biochemical Analysis Reveal a Noncanonical Function for UFM1-Specific Protease 1 in the p62 Body Formation., PMID:37285312
Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling., PMID:37131258
Ufmylation bridges autophagy and ER homeostasis in plants., PMID:37126567
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila., PMID:37086384
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells., PMID:37017084
Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target., PMID:36893266
UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses., PMID:36843575
Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis., PMID:36743909
Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis., PMID:36696447
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3., PMID:36543799
Emerging role of protein modification by UFM1 in cancer., PMID:36344165
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation., PMID:36121123
Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation., PMID:35931931
UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation., PMID:35871231
Overexpression of UBA5 in Cells Mimics the Phenotype of Cells Lacking UBA5., PMID:35806453
For research use only. Not for human or drug use.
