Catalog No.
YHG98401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly278-Gly436
Predicted molecular weight
19.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15031
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leucyl-tRNA synthetase, LeuRS, KIAA0028, LARS2, Probable leucine--tRNA ligase, mitochondrial
Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression network., PMID:40230854
Novel compound heterozygous mutations in the LARS2 gene in a Chinese family with hearing loss., PMID:39762667
YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix., PMID:39551603
Novel Cases of Non-Syndromic Hearing Impairment Caused by Pathogenic Variants in Genes Encoding Mitochondrial Aminoacyl-tRNA Synthetases., PMID:39062730
Exome sequencing reveals pathogenic mutations in the LARS2 and HSD17B4 genes associated with Perrault syndrome and D-bifunctional protein deficiency in Moroccan families., PMID:39052101
Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis., PMID:38937317
Diagnostic value of lncRNAs LINC00152 and LARS2-AS1 and their regulatory roles in macrophage immune response in tuberculosis., PMID:38857553
A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes., PMID:38832431
Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury., PMID:38745657
Investigating gene signatures associated with immunity in colon adenocarcinoma to predict the immunotherapy effectiveness using NFM and WGCNA algorithms., PMID:38742936
Regulating Lars2 in mitochondria: A potential Alzheimer's therapy by inhibiting tau phosphorylation., PMID:38575503
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization., PMID:38458203
[Analysis of perrault syndrome caused by pathogenic variants in LARS2 and HARS2 genes]., PMID:38186093
Axonal polyneuropathy and ataxia in children: consider Perrault Syndrome, a case report., PMID:37932750
Comparative transcriptome and proteome analysis explores the antitumor key regulators of ergosterone in H22 tumor-bearing mice., PMID:37290681
Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2., PMID:37039265
Ataxia and Hypogonadism: a Review of the Associated Genes and Syndromes., PMID:36997834
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle., PMID:36796135
An encounter with the mild side of LARS2-associated Perrault syndrome and its implications on the diagnostic odyssey., PMID:36693951
LARS2 variants can present as premature ovarian insufficiency in the absence of overt hearing loss., PMID:36450801
Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression., PMID:36436798
Neonatal lactic acidosis explained by LARS2 defect., PMID:35750896
Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion., PMID:35659337
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells., PMID:35585880
Comprehensive Characterization of RNA-Binding Proteins in Colon Adenocarcinoma Identifies a Novel Prognostic Signature for Predicting Clinical Outcomes and Immunotherapy Responses Based on Machine Learning., PMID:35379120
Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter., PMID:35217815
Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice., PMID:35217814
Predicting pathogenicity for novel hearing loss mutations based on genetic and protein structure approaches., PMID:34997062
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA., PMID:34943861
Genetics of ovarian insufficiency and defects of folliculogenesis., PMID:34794894
Exploring the Ability of LARS2 Carboxy-Terminal Domain in Rescuing the MELAS Phenotype., PMID:34357047
New insights into Perrault syndrome, a clinically and genetically heterogeneous disorder., PMID:34338890
Integrated Analysis of the Roles of RNA Binding Proteins and Their Prognostic Value in Clear Cell Renal Cell Carcinoma., PMID:34306592
Several Fusion Genes Identified in a Spermatic Cord Leiomyoma With Rearrangements of Chromosome Arms 3p and 21q., PMID:34183386
Activity of blinatumomab in lymphoblastic leukemia with impaired T-cell immunity due to congenital immunodeficiency., PMID:33881461
Gene promoter polymorphisms in boar spermatozoa differing in freezability., PMID:33735665
Single-Cell Transcriptional Profiling Reveals Sex and Age Diversity of Gene Expression in Mouse Endothelial Cells., PMID:33679877
Novel Mutations in CLPP, LARS2, CDH23, and COL4A5 Identified in Familial Cases of Prelingual Hearing Loss., PMID:32842620
Perrault syndrome: Clinical report and retrospective analysis., PMID:32767731
Construction of a 14-lncRNA risk score system predicting survival of children with acute myelocytic leukemia., PMID:32742384
The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy., PMID:32442335
LARS2-Perrault syndrome: a new case report and literature review., PMID:32423379
Genomic sequencing highlights the diverse molecular causes of Perrault syndrome: a peroxisomal disorder (PEX6), metabolic disorders (CLPP, GGPS1), and mtDNA maintenance/translation disorders (LARS2, TFAM)., PMID:32399598
Mitochondrial Dysfunction in Primary Ovarian Insufficiency., PMID:31393557
Perrault syndrome with amenorrhea, infertility, Tarlov cyst, and degenerative disc., PMID:31274036
Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy., PMID:30737337
Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish., PMID:30262142
Identification and Characterization of Chemical Compounds that Inhibit Leucyl-tRNA Synthetase from Pseudomonas aeruginosa., PMID:30088448
An Epigenome-Wide Association Study of Obesity-Related Traits., PMID:29762635
For research use only. Not for human or drug use.
