Catalog No.
YHA54901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro2-Leu85
Predicted molecular weight
22.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15503
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Insulin-induced gene 1 protein, INSIG1, INSIG-1
TRIM25-Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism., PMID:40231613
The modulatory effect of pea resistant starch on hyperlipidemia in high fat diet-induced obese mice is related to their supramolecular structural features., PMID:40165353
Effects of candidate genes on milk fat synthesis in ruminants: A meta-analysis., PMID:40139354
Animal Model Screening for Hyperlipidemic ICR Mice., PMID:40076768
A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours., PMID:40065102
Molecular Characteristics and Role of Buffalo SREBF2 in Triglyceride and Cholesterol Biosynthesis in Mammary Epithelial Cells., PMID:40004566
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation., PMID:39977267
Reconstruction and computer analysis of the structural and functional organization of the gene network regulating cholesterol biosynthesis in humans and the evolutionary characteristics of the genes involved in the network., PMID:39944801
Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms., PMID:39898321
Near-infrared light therapy normalizes amyloid load, neuronal lipid membrane order, rafts and cholesterol level in Alzheimer's disease., PMID:39724841
Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma., PMID:39692168
Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice., PMID:39627188
SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice., PMID:39476450
A data mining approach to identify key radioresponsive genes in mouse model of radiation-induced intestinal injury., PMID:39431989
Canola Oil Ameliorates Obesity by Suppressing Lipogenesis and Reprogramming the Gut Microbiota in Mice via the AMPK Pathway., PMID:39408346
Overexpression of PER2 Promotes De Novo Fatty Acid Synthesis, Fatty Acid Desaturation, and Triglyceride Accumulation in Bovine Mammary Epithelial Cells., PMID:39337271
FABP1 induces lipogenesis by regulating the processing of SREBP1 in hepatocytes of large yellow croaker (Larimichthys crocea)., PMID:39275940
Radix Rehmanniae Praeparata extracts ameliorate hepatic ischemia-reperfusion injury by restoring lipid metabolism in hepatocytes., PMID:39168395
Control of innate immunity and lipid biosynthesis in neurodegeneration., PMID:39156128
Phosphorylation of Insig-2 mediates inhibition of fatty acid synthesis by polyunsaturated fatty acids., PMID:39145929
Insulin-Induced Gene 1-Enhance Secretion of BMSC Exosome Enriched in miR-132-3p Promoting Wound Healing in Diabetic Mice., PMID:39136964
Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1., PMID:39103107
[Study on multiple organ injury induced by Haematitum in mice]., PMID:39041163
Circular RNA_015343 sponges microRNA-25 to regulate viability, proliferation, and milk fat synthesis of ovine mammary epithelial cells via INSIG1., PMID:38828915
Tubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis., PMID:38806641
Interaction of de novo cholesterol biosynthesis and Hippo signaling pathway in ductal carcinoma in situ (DCIS)-comparison with the corresponding normal breast epithelium., PMID:38751474
The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells., PMID:38247876
Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs)., PMID:38203671
Integrated bioinformatics and validation to construct lncRNA-miRNA-mRNA ceRNA network in status epilepticus., PMID:38074882
UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR., PMID:38067172
Identification of postnatal development dependent genes and proteins in porcine epididymis., PMID:38049726
SARS-CoV-2 papain-like protease plays multiple roles in regulating cellular proteins in the endoplasmic reticulum., PMID:37838170
HUB genes transcriptionally regulate lipid metabolism in alveolar type II cells under LPS stimulation., PMID:37662799
Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer., PMID:37491786
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis., PMID:37451670
Low abundance of insulin-induced gene 1 contributes to SREBP-1c processing and hepatic steatosis in dairy cows with severe fatty liver., PMID:37291038
A novel deformable liposomal hydrogel loaded with a SREBP-1-inhibiting polypeptide for reducing sebum synthesis in golden hamster model., PMID:37268093
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer., PMID:37087475
Functional differentiation of the ovine preadipocytes -insights from gene expression profiling., PMID:36952056
Effect of Cow-Calf Supplementation on Gene Expression, Processes, and Pathways Related to Adipogenesis and Lipogenesis in Longissimus thoracis Muscle of F1 Angus × Nellore Cattle at Weaning., PMID:36837780
Salvianolic acid A alleviates atherosclerosis by inhibiting inflammation through Trc8-mediated 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation., PMID:36804757
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout., PMID:36745138
Functional and miRNA regulatory characteristics of INSIG genes highlight the key role of lipid synthesis in the liver of chicken (Gallus gallus)., PMID:36571872
Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis., PMID:35805937
Identification of Key Genes as Early Warning Signals of Acute Myocardial Infarction Based on Weighted Gene Correlation Network Analysis and Dynamic Network Biomarker Algorithm., PMID:35795669
Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway., PMID:35691075
Functional roles for AGPAT6 in milk fat synthesis of buffalo mammary epithelial cells., PMID:35649414
The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1., PMID:35637957
Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer., PMID:35631531
Deoxynivalenol exposure inhibits biosynthesis of milk fat and protein by impairing tight junction in bovine mammary epithelial cells., PMID:35447471
For research use only. Not for human or drug use.
