Catalog No.
YHF61501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg175
Predicted molecular weight
22.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P67870
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CSNK2B, G5A, CK2N, Protein G5a, Casein kinase II subunit beta, CK II beta, Phosvitin
Pathogenic missense variants of CSNK2B associated with Poirier-Bienvenu neurodevelopmental disorder impact differently on CK2 holoenzyme formation., PMID:40317201
Genetic analysis of four cases of Poirier Bienvenu neurodevelopmental syndrome associated with CSNK2B variant., PMID:40211296
Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study., PMID:40062439
Disruption of circadian intraocular pressure fluctuations in mice by the Lyst beige-J mutation., PMID:39894294
Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B., PMID:39718697
Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies., PMID:39003674
Exploration of mitochondrial autophagy related genes in the diagnosis model construction and molecular marker mining of Alzheimer's disease based on multi-omics integration., PMID:38836671
RACK1 Promotes Meningioma Progression by Activation of NF-κB Pathway via Preventing CSNK2B from Ubiquitination Degradation., PMID:38398158
Genetic analysis and literature review of a Poirier-Bienvenu neurodevelopmental syndrome family line caused by a de novo frameshift variant in CSNK2B., PMID:38037515
CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins., PMID:37938186
Proteomic analysis of anti-aging effects of Dendrobium nobile Lindl. alkaloids in aging-accelerated SAMP8 mice., PMID:37150330
CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling., PMID:37094077
Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B., PMID:37022795
Haploinsufficiency as a Foreground Pathomechanism of Poirer-Bienvenu Syndrome and Novel Insights Underlying the Phenotypic Continuum of CSNK2B-Associated Disorders., PMID:36833176
Identification of radiation responsive RBC membrane associated proteins (RMAPs) in whole-body γ-irradiated New Zealand white rabbits., PMID:36718137
MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell Proliferation via a CSNK2B/CDK4 Axis., PMID:36617978
In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2α Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions., PMID:36552726
Predictive functional, statistical and structural analysis of CSNK2A1 and CSNK2B variants linked to neurodevelopmental diseases., PMID:36310603
De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway., PMID:35571680
Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers., PMID:35383147
Identification of a seven-gene prognostic signature using the gene expression profile of osteosarcoma., PMID:35282067
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes., PMID:35169297
Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection., PMID:34914966
Clinical and genetic analysis of six Chinese children with Poirier-Bienvenu neurodevelopmental syndrome caused by CSNK2B mutation., PMID:34370157
6p21.33 Deletion encompassing CSNK2B is associated with relative macrocephaly, facial dysmorphism, and mild intellectual disability., PMID:33758130
Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression., PMID:33526068
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction., PMID:33483422
Poirier-Bienvenu neurodevelopmental syndrome: A report of a patient with a pathogenic variant in CSNK2B with abnormal linear growth., PMID:33166063
Antitumor Activity and Mechanism of Robustic Acid from Dalbergia benthami Prain via Computational Target Fishing., PMID:32867345
Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress., PMID:32673694
Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma., PMID:32448607
Tumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks nuclear factor-κB activation in hepatocellular carcinoma., PMID:31901862
Germline de novo variants in CSNK2B in Chinese patients with epilepsy., PMID:31784560
Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons., PMID:31779225
Loss of Protein Kinase Csnk2b/CK2β at Neuromuscular Junctions Affects Morphology and Dynamics of Aggregated Nicotinic Acetylcholine Receptors, Neuromuscular Transmission, and Synaptic Gene Expression., PMID:31434353
Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia., PMID:30705251
Identification of de novo CSNK2A1 and CSNK2B variants in cases of global developmental delay with seizures., PMID:30655572
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes., PMID:29483533
In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy., PMID:29165030
Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer., PMID:29071797
Truncating mutation in CSNK2B and myoclonic epilepsy., PMID:28762608
CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy., PMID:28585349
Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ+ Th1/Tregs., PMID:27635087
Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development., PMID:27527857
Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination., PMID:27100886
RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS., PMID:27094248
Integrated molecular analysis of adult T cell leukemia/lymphoma., PMID:26437031
Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome., PMID:26172092
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy., PMID:25837326
Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention., PMID:25327614
For research use only. Not for human or drug use.
