Catalog No.
YHE06601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser24-Lys113
Predicted molecular weight
22.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P34998
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRH-R1, CRHR1, CRFR, CRFR-1, Corticotropin-releasing factor receptor 1, CRFR1, CRF-R1, CRF-R-1, Corticotropin-releasing hormone receptor 1, CRHR, CRH-R-1
Predator odor stress produces sex- and subpopulation-specific increases in alcohol drinking, anxiety-like behavior, and lateral hypothalamic Crh expression., PMID:40374160
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1., PMID:40220965
The effects of stress and environmental enrichment on cognitive functions and stress-related gene expressions in the brain of aged rats., PMID:40116421
Mast cells and corticotropin-releasing hormone receptors in duodenal tissue of children with functional dyspepsia., PMID:40050228
Brain monoamine changes modulate the corticotropin-releasing hormone receptor 1-mediated behavioural response to acute thermal stress in zebrafish larvae., PMID:39956313
Corticotropin-releasing hormone receptor 1 mediates the enhanced locomotor activity and metabolic demands to an acute thermal stress in adult zebrafish., PMID:39915694
Development of a Genetic Test Indicating Increased AVP/V1b Signalling in Patients with Acute Depression., PMID:39880002
Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction., PMID:39875474
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone., PMID:39715892
Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse., PMID:39692887
Increased CRF-R1 transmission in the nucleus accumbens shell facilitates maternal neglect in lactating rats and mediates anxiety-like behaviour in a sex-specific manner., PMID:39647775
Single Intranasal Administration of Ucn3 Affects the Development of PTSD Symptoms in an Animal Model., PMID:39595978
Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice., PMID:39578519
Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake., PMID:39466414
Dorsal CA1 NECTIN3 Reduction Mediates Early-Life Stress-Induced Object Recognition Memory Deficits in Adolescent Female Mice., PMID:39395912
Restoring social deficits in IRSp53-deleted mice: chemogenetic inhibition of ventral dentate gyrus Emx1-expressing cells., PMID:39375329
Increased CRHR1 expression on monocytes from patients with AA enables a pro-inflammatory response to corticotrophin-releasing hormone., PMID:39367575
Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling., PMID:39356686
Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway., PMID:39349483
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats., PMID:39327618
Precision Psychiatry Approach to Treat Depression and Anxiety Targeting the Stress Hormone System - V1b-antagonists as a Case in Point., PMID:39159843
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology., PMID:39134740
Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin-releasing factor and estrogen regulation in male and female mice., PMID:39080914
Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder., PMID:39029702
Manipulation of a social signal affects DNA methylation of a stress-related gene in a free-living bird., PMID:39022893
Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology., PMID:39014514
Hippocampal Crhr1 conditional gene knockout ameliorated the depression-like behavior and pathological damage in male offspring mice caused by chronic stress during pregnancy., PMID:38969017
CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression., PMID:38823676
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of squalene against inflammation., PMID:38756678
Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies., PMID:38706793
Integrative clinical, hormonal, and molecular data associate with invasiveness in acromegaly: REMAH study., PMID:38701338
GSDMB/ORMDL3 Rare/Common Variants Are Associated with Inhaled Corticosteroid Response among Children with Asthma., PMID:38674355
Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes., PMID:38673790
Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin release factor and estrogen regulation., PMID:38659848
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix., PMID:38625939
CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats., PMID:38601362
Response of CRH system in brain and gill of marine medaka to seawater acidification., PMID:38512395
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder., PMID:38509197
Paeoniflorin Alleviates Anxiety and Visceral Hypersensitivity via HPA Axis and BDNF/TrkB/PLCγ1 Pathway in Maternal Separation-induced IBS-like Rats., PMID:38494933
Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression., PMID:38419452
Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness., PMID:38395991
The effects of childhood maltreatment, recent interpersonal and noninterpersonal stress, and HPA-axis multilocus genetic variation on prospective changes in adolescent depressive symptoms: A multiwave longitudinal study., PMID:38389485
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells., PMID:38368491
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response., PMID:38301651
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology., PMID:38293137
Early life adversity accelerates hypothalamic drive of pubertal timing in female rats with associated enhanced acoustic startle., PMID:38241961
Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit., PMID:38241377
Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin., PMID:38133877
LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity., PMID:38092990
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination., PMID:38008372
For research use only. Not for human or drug use.
