Catalog No.
YHK20801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His433
Predicted molecular weight
51.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRG4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HSKM-B, N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SMYD2, SET and MYND domain-containing protein 2, Lysine N-methyltransferase 3C, KMT3C
SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity., PMID:40391402
Mechanism of SMYD2 promoting stemness maintenance of bladder cancer stem cells by regulating PYCR1 expression and PINK1/Parkin mitophagy pathway., PMID:40341538
Role of SMYD2 in gastrointestinal cancer progression (Review)., PMID:40242267
Histone methyltransferase SMYD2 regulates the activation of hepatic stellate cells by activating TLR4 signaling., PMID:40240419
The Olive Oil Phenolic S-(-)-Oleocanthal Suppresses Colorectal Cancer Progression and Recurrence by Modulating SMYD2-EZH2 and c-MET Activation., PMID:39940255
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion., PMID:39682718
Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding., PMID:39677743
A novel hypoxia-induced lncRNA, SZT2-AS1, boosts HCC progression by mediating HIF heterodimerization and histone trimethylation under a hypoxic microenvironment., PMID:39572656
H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3., PMID:39109795
Targeting SMYD2 promotes ferroptosis and impacts the progression of pancreatic cancer through the c-Myc/NCOA4 axis-mediated ferritinophagy., PMID:39089637
Synergistic anticancer effects of SMYD2 inhibitor BAY-598 and doxorubicin in non-small cell lung cancer., PMID:38947456
Inhibition of SMYD2 attenuates paraquat-induced pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition through the GLIPR2/ERK/p38 axis., PMID:38879290
SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy., PMID:38770649
SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell-cycle inhibitors to guide tissue formation., PMID:38758030
Methylation of ESCRT-III components regulates the timing of cytokinetic abscission., PMID:38740816
SMYD2 induced PGC1α methylation promotes stemness maintenance of glioblastoma stem cells., PMID:38721826
Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer., PMID:38700982
Epigenetic regulators controlling osteogenic lineage commitment and bone formation., PMID:38341164
Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis., PMID:38296970
Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide., PMID:38243079
Regulation of adipogenesis by histone methyltransferases., PMID:38241884
Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2., PMID:38160530
Neutrophil extracellular traps promote gastric cancer cell metastasis via the NAT10-mediated N4-acetylcytidine modification of SMYD2., PMID:38110168
Computational approach for assessing the involvement of SMYD2 protein in human cancers using TCGA data., PMID:37971632
SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma Cells by Upregulating EVI2A., PMID:37812330
Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis., PMID:37790557
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation., PMID:37673879
SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin., PMID:37615725
Pharmacological inhibition of SMYD2 protects against cisplatin-induced renal fibrosis and inflammation., PMID:37524453
Dissecting the Role of SMYD2 and Its Inhibitor (LLY-507) in the Treatment of Chemically Induced Non-Small Cell Lung Cancer (NSCLC) by Using Fe3O4 Nanoparticles Drug Delivery System., PMID:37513898
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity., PMID:37315132
Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma., PMID:37232506
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis., PMID:37121971
SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin., PMID:37090651
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease., PMID:37040760
Targeting SMYD2 inhibits prostate cancer cell growth by regulating c-Myc signaling., PMID:37036190
SMYD2 Expression: Its Relationship to Cytogenetic and Prognosis in a Newly Diagnosed Childhood B-Acute Lymphoblastic Leukemia., PMID:36912291
Targeting Epigenetic Changes Mediated by Members of the SMYD Family of Lysine Methyltransferases., PMID:36838987
SMYD Family Members Serve as Potential Prognostic Markers and Correlate with Immune Infiltrates in Gastric Cancer., PMID:36816359
SMYD2 Promotes Hepatocellular Carcinoma Progression by Reprogramming Glutamine Metabolism via c-Myc/GLS1 Axis., PMID:36611819
Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity., PMID:36585926
Effect of miRNA-200b on the proliferation of liver cancer cells via targeting SMYD2/p53 signaling pathway., PMID:36411681
Clinical prognostic value of the SMYD2/3 as new epigenetic biomarkers in solid cancer patients: a systematic review and meta-analysis., PMID:36346387
Transcriptomic and proteomic time-course analyses based on Metascape reveal mechanisms against muscle atrophy in hibernating Spermophilus dauricus., PMID:36280225
Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation., PMID:36270984
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization., PMID:36191822
Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer., PMID:36157542
Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice., PMID:36046818
STUB1-SMYD2 Axis Regulates Drug Resistance in Glioma cells., PMID:35939202
Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy., PMID:35914250
For research use only. Not for human or drug use.
