Catalog No.
YHG18101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys422
Predicted molecular weight
50.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08945
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Recombination signal sequence recognition protein 1, SSRP1, FACT 80 kDa subunit, Chromatin-specific transcription elongation factor 80 kDa subunit, T160, FACT complex subunit SSRP1, FACTp80, FACT80, Structure-specific recognition protein 1, hSSRP1, Facilitates chromatin transcription complex subunit SSRP1, Facilitates chromatin transcription complex 80 kDa subunit
Therapeutic potential of miR-204-5p in intervertebral disc degeneration: targeting the SSRP1/NF-κB pathway to inhibit apoptosis., PMID:40514727
Beyond Chaperoning: The Multifaceted Role of FACT in Chromatin Transactions., PMID:40507984
A Novel ceRNA Axis LOC121818100/Novel-miR-400/SSRP1 Regulated Muscle Growth and Injury Repair in Sheep., PMID:40468947
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27., PMID:40391177
SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T-Cell Lymphoma., PMID:40344476
Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT., PMID:40094435
Activation and Evasion of the FEAR Pathway by RNA Viruses., PMID:40060670
Pseudokinase TRIB3 stabilizes SSRP1 via USP10-mediated deubiquitination to promote multiple myeloma progression., PMID:39653795
Evolution of the chromatin remodeling complex FACT: Functional analysis of SSRP1 and SPT16 in early anther development., PMID:39615716
The protein composition of human adenovirus replication compartments., PMID:39611842
Facilitates Chromatin Transcription in Breast and Other Cancers., PMID:39586994
RSF1 orchestrates p53 transcriptional activity by coordinating p300 acetyltransferase and FACT complex., PMID:39579530
FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair., PMID:39251545
FACT mediates the depletion of macroH2A1.2 to expedite gene transcription., PMID:39116874
MiR-204/-211 double knockout exacerbates rheumatoid arthritis progression by promoting splenic inflammation., PMID:39116488
The HMG-box module in FACT is critical for suppressing epigenetic variegation of heterochromatin in fission yeast., PMID:38837646
FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo., PMID:38810649
The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells., PMID:38719542
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes., PMID:38517892
Chromatin damage generated by DNA intercalators leads to degradation of RNA Polymerase II., PMID:38340348
Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin., PMID:38213626
Transcriptional regulation of FACT involves Coordination of chromatin accessibility and CTCF binding., PMID:38072046
Targeting FAcilitates Chromatin Transcription complex inhibits pleural mesothelioma and enhances immunotherapy., PMID:37974213
Quantifying ATP-Independent Nucleosome Chaperone Activity with Single-Molecule Methods., PMID:37823998
Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach., PMID:37605650
SFPQ promotes the proliferation, migration and invasion of hepatocellular carcinoma cells and is associated with poor prognosis., PMID:37424798
Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1., PMID:37084412
Structural basis for H2A-H2B recognitions by human Spt16., PMID:36801613
A FACT-ETS-1 Antiviral Response Pathway Restricts Viral Replication and is Countered by Poxvirus A51R Proteins., PMID:36798356
Bioinformatics and System Biology Techniques to Determine Biomolecular Signatures and Pathways of Prion Disorder., PMID:36582393
Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes., PMID:36577379
CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors., PMID:36539830
Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1., PMID:36511897
Therapeutic targeting the oncogenic driver EWSR1::FLI1 in Ewing sarcoma through inhibition of the FACT complex., PMID:36357572
Oncogenic Role of HMGB1 as An Alarming in Robust Prediction of Immunotherapy Response in Colorectal Cancer., PMID:36230798
Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma., PMID:36059151
FACT modulates the conformations of histone H2A and H2B N-terminal tails within nucleosomes., PMID:35963897
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling., PMID:35904816
Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced stemness and cisplatin resistance in nasopharyngeal carcinoma side population cells through the miR-579-3p/SIRT1/SSRP1 axis., PMID:35844005
Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer., PMID:35831348
Expression of MCMs in Endometrial Cancer and its Biological Correlation Analysis., PMID:35792121
Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis., PMID:35489065
Role of lncSLCO1C1 in gastric cancer progression and resistance to oxaliplatin therapy., PMID:35474446
The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead., PMID:35463672
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones., PMID:35320725
SSRP1 affects the growth and apoptosis of gastric cancer cells through AKT pathway., PMID:35291495
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3., PMID:35230915
FACT maintains nucleosomes during transcription and stem cell viability in adult mice., PMID:35179289
Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma., PMID:35048565
Electron microscopy analysis of ATP-independent nucleosome unfolding by FACT., PMID:35013515
For research use only. Not for human or drug use.
