Catalog No.
YHG08601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg30-Gly345
Predicted molecular weight
38.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q06330
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Recombining binding protein suppressor of hairless, RBP-J, IGKJRB, CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, IGKJRB1, RBPJ, Renal carcinoma antigen NY-REN-30, RBPSUH, RBPJK
Role of Estrogen Signaling in Notch Pathway Activation in Sertoli Cells., PMID:40506655
RBPJ/PAF1 Signaling Axis Promotes Cloning Expansion in Paroxysmal Nocturnal Hemoglobinuria Through NOTCH Signaling., PMID:40501337
Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer., PMID:40365281
Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression., PMID:40343501
Targeting endothelial MYC using siRNA or miR-218 nanoparticles sensitizes chemo- and immuno-therapies by recapitulating the Notch activation-induced tumor vessel normalization., PMID:40303332
Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength., PMID:40295915
Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia., PMID:40208437
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3., PMID:40140585
Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells., PMID:40120139
Notch dependent chromatin remodeling enables Gata3 binding and drives lineage specific CD8+ T cell function., PMID:40012375
Notch signaling in osteoblast progenitor cells is required for BMP-induced bone formation., PMID:39978612
NOTCH1 promotes the elevation of GM-CSF and IL-6 through the EZH2/STAT3 pathway to facilitate the fibrotic state of the myocardium in DLBCL., PMID:39951437
Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription., PMID:39901144
Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding., PMID:39893191
CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation., PMID:39890825
Involvement of RBP-J interacting and tubulin-associated protein in the distribution of protein regulator of cytokinesis 1 in mitotic spindles., PMID:39839673
Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers., PMID:39819837
Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling pathways., PMID:39737592
TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the Notch signaling pathway., PMID:39725730
[MiR-139-5p regulates the Notch/RBP-J/Hes1 axis to promote homing of bone mesenchymal stem cells in bronchial asthma]., PMID:39725616
AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription., PMID:39724412
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity., PMID:39666740
Luteolin ameliorates ulcerative colitis in mice via reducing the depletion of NCR+ILC3 through Notch signaling pathway., PMID:39510641
Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer., PMID:39478150
The expression of RBPJ and its potential role in rheumatoid arthritis., PMID:39350019
Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study., PMID:39324142
Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease., PMID:39317200
Methyltransferase-Like 3-Driven N6-Methyladenosine Modification of Recombination Signal Binding Protein for Immunoglobulin Kappa J Region Promotes Vascular Remodeling in Pulmonary Hypertension., PMID:39222906
PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up., PMID:39147880
ETS1 and RBPJ transcriptionally regulate METTL14 to suppress TGF-β1-induced epithelial-mesenchymal transition in human bronchial epithelial cells., PMID:39002703
Dtx2 Deficiency Induces Ependymo-Radial Glial Cell Proliferation and Improves Spinal Cord Motor Function Recovery., PMID:39001828
Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina., PMID:38996013
The cellular Notch1 protein promotes KSHV reactivation in an Rta-dependent manner., PMID:38975769
Origin recognition complex 6 overexpression promotes growth of glioma cells., PMID:38971772
Curcuminoid PBPD induces cuproptosis and endoplasmic reticulum stress in cervical cancer via the Notch1/RBP-J/NRF2/FDX1 pathway., PMID:38801356
FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers., PMID:38774470
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis., PMID:38761249
Dual Deletion of Keap1 and Rbpjκ Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia., PMID:38731931
Rbpj deletion in hepatic progenitor cells attenuates endothelial responses in a mouse model of cholestatic liver disease., PMID:38659780
Comprehensive genomic features indicative for Notch responsiveness., PMID:38647081
Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia., PMID:38632887
Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse., PMID:38538986
Hypoxic environment promotes angiogenesis and bone bridge formation by activating Notch/RBPJ signaling pathway in HUVECs., PMID:38537807
Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome., PMID:38475709
RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells., PMID:38459621
RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes., PMID:38407952
m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways., PMID:38369001
MiR-223-3p attenuates M1 macrophage polarization via suppressing the Notch signaling pathway and NLRP3-mediated pyroptosis in experimental autoimmune uveitis., PMID:38059448
DNA methylation-mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation., PMID:38051594
Post-transcriptional regulation of grain weight and shape by the RBP-A-J-K complex in rice., PMID:37970747
For research use only. Not for human or drug use.
