Catalog No.
YHE99201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly419-Asp647
Predicted molecular weight
28.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53667
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIMK-1, LIMK, LIMK1, LIM domain kinase 1
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5., PMID:40476449
TNIK Regulates Cytoskeletal Organization to Promote Focal Adhesion Turnover and Mitosis in Lung Adenocarcinoma., PMID:40464520
Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer's disease., PMID:40461464
Using CE to confirm the activity of fluorescent miRFP670-LIMK1 protein produced for MST assays directly in cell lysate., PMID:40409904
Androgen receptor plays critical role in regulating cervical cancer cell migration., PMID:40409531
Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway., PMID:40392868
Design, optimization, and ADMET evaluation of S11a-0000168202: A promising LIMK1 inhibitor for gastric cancer treatment., PMID:40367093
Spatiotemporal expression of Nischarin in developing rat brain mediates neuronal migration via the PAK1/LIMK1/cofilin pathway., PMID:40262669
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor., PMID:40227881
Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats., PMID:40210127
RAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1/PAK1/LIMK1 signaling pathway., PMID:40087375
Identification of LIMK1 as a biomarker in clear cell renal cell carcinoma: from data mining to validation., PMID:40056237
Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork., PMID:39990379
Ginsenoside Rh2(S) maintains cytoskeleton homeostasis and inhibits pyroptosis to resist cisplatin-induced cardiotoxicity through FGFR1/HRAS axis., PMID:39879704
Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome., PMID:39711116
Structural and functional alterations of neurons derived from sporadic Alzheimer's disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis., PMID:39702316
Unraveling the role of SSH1 in chronic neuropathic pain: A focus on LIMK1 and Cofilin Dephosphorylation in the prefrontal cortex., PMID:39701356
Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes., PMID:39611817
Bisphenol A disrupts the neuronal F-actin cytoskeleton by activating the RhoA/ROCK/LIMK pathway in Neuro-2a cells., PMID:39527977
Identification of Sequential Molecular Mechanisms and Key Biomarkers in Early Glaucoma by Integrated Bioinformatics Analysis., PMID:39495230
p57Kip2 Phosphorylation Modulates Its Localization, Stability, and Interactions., PMID:39456957
Design, synthesis and biological evaluation of novel benzimidazole-derived p21-activited kinase 4 (PAK4) inhibitors bearing a 4-(4-methylpiperazin-1-yl)phenyl scaffold as potential antitumor agents., PMID:39427518
DDAH1 deficiency exacerbates cerebral vascular endothelial dysfunction by aggravating BBB disruption and oxidative stress in thoracic blast-induced brain injury., PMID:39424041
Regulation of Bone Morphogenetic Protein Receptor Type II Expression by FMR1/Fragile X Mental Retardation Protein in Human Granulosa Cells in the Context of Poor Ovarian Response., PMID:39408972
Regulation and signaling of the LIM domain kinases., PMID:39361252
Whole-Genome and Poly(A)+Transcriptome Analysis of the Drosophila Mutant agnts3 with Cognitive Dysfunctions., PMID:39337379
New targets and designed inhibitors of ASAP Arf-GAPs derived from structural characterization of the ASAP1/440-kD ankyrin-B interaction., PMID:39265663
Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice., PMID:39265451
NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target., PMID:39197295
B7-H3 promotes the migration and invasion of colorectal cancer cells via regulating the actin cytoskeleton and RhoA/ROCK1/LIMK1 signaling pathway., PMID:39173456
LIM kinase 2 activates cardiac fibroblasts and exacerbates postinfarction left ventricular remodeling via crosstalk between the canonical and non-canonical Wnt pathways., PMID:39153710
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice., PMID:39099385
Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase., PMID:39080357
Tandem LIM domain-containing proteins, LIMK1 and LMO1, directly bind to force-bearing keratin intermediate filaments., PMID:39003737
LIMK1 promotes the development of cervical cancer by up-regulating the ROS/Src-FAK/cofilin signaling pathway., PMID:38975937
Targeting MAD2B as a strategy for ischemic stroke therapy., PMID:38972542
PAK2 promotes proliferation, migration, and invasion of lung squamous cell carcinoma through LIMK1/cofilin signaling pathway., PMID:38828848
RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation., PMID:38809020
TAZ is involved in breast cancer cell migration via regulating actin dynamics., PMID:38774409
PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior., PMID:38747058
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization., PMID:38669909
Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males., PMID:38648760
Systematic identification and characterization of exon-intron circRNAs., PMID:38609186
The role of miRNA134 in pathogenesis and treatment of intractable epilepsy: a review article., PMID:38531025
Investigating LIM (Lin-11, Isl-1, and Mec-3) Kinases and Their Correlation with Pathological Events and Microtubule Dynamics in an Experimental Model of Spinal Cord Injury in Rats., PMID:38481685
PAK1-Dependent Regulation of Microtubule Organization and Spindle Migration Is Essential for the Metaphase I-Metaphase II Transition in Porcine Oocytes., PMID:38397472
Myocardial fibrosis induced by nonylphenol and its regulatory effect on the TGF-β1/LIMK1 signaling pathway., PMID:38364763
Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway., PMID:38330925
An essential role for the RNA helicase DDX6 in NMDA receptor-dependent gene silencing and dendritic spine shrinkage., PMID:38321143
Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes., PMID:38238555
For research use only. Not for human or drug use.
