Catalog No.
YHD49301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg105-Ser230
Predicted molecular weight
17.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22001
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HGK5, Voltage-gated K(+) channel HuKIII, HLK3, KCNA3, Potassium voltage-gated channel subfamily A member 3, HPCN3, Voltage-gated potassium channel subunit Kv1.3
Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding., PMID:40409708
Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head., PMID:40102965
Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR)., PMID:40035659
Identification of KCNJ5 gene an adverse prognosis associated novel onco-ionchannel in Indian pancreatic cancer cohort., PMID:39998707
Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding., PMID:39868087
Kv1.3-induced hyperpolarization is required for efficient Kaposi's sarcoma-associated herpesvirus lytic replication., PMID:39012937
Effect of the rs2821557 Polymorphism of the Human Kv1.3 Gene on Olfactory Function and BMI in Different Age Groups., PMID:38542732
De novo variants in KCNA3 cause developmental and epileptic encephalopathy., PMID:37964487
Selective Block of Upregulated Kv1.3 Potassium Channels in ON-Bipolar Cells of the Blind Retina Enhances Optogenetically Restored Signaling., PMID:37762510
Characterization of endogenous Kv1.3 channel isoforms in T cells., PMID:36852591
Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome., PMID:36440534
A Potential Anticancer Mechanism of Finger Root (Boesenbergia rotunda) Extracts against a Breast Cancer Cell Line., PMID:36106139
Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-κB signaling pathway., PMID:36100082
Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators., PMID:35788586
Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells., PMID:35328733
Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration., PMID:35241647
GFP-Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers., PMID:35163644
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug., PMID:35091471
Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels., PMID:34662565
Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes., PMID:34639190
The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion., PMID:34617690
Identification of Early Diagnostic and Prognostic Biomarkers via WGCNA in Stomach Adenocarcinoma., PMID:34221961
A novel mitochondrial Kv1.3-caveolin axis controls cell survival and apoptosis., PMID:34196606
Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease., PMID:34101221
Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism., PMID:33828089
Different pharmacological properties between scorpion toxin BmKcug2 and its degraded analogs highlight the diversity of K+ channel blockers from thermally processed scorpions., PMID:33636268
Non-dioxin-like polychlorinated biphenyl 19 has distinct effects on human Kv1.3 and Kv1.5 channels., PMID:33316272
DNA Methylation Profiling of Human Hepatocarcinogenesis., PMID:33237575
Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation., PMID:33230847
Mutual regulation between β-TRCP mediated REST protein degradation and Kv1.3 expression controls vascular smooth muscle cell phenotype switch., PMID:33038663
Intracellular fluoride influences TASK mediated currents in human T cells., PMID:33031794
Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice., PMID:32956412
Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region., PMID:32863001
Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes., PMID:32823677
Role of Kv1.3 Channels in Platelet Functions and Thrombus Formation., PMID:32787516
Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata., PMID:32411613
Application of Multiplex Bisulfite PCR-Ligase Detection Reaction-Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer., PMID:32407802
A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis., PMID:32056271
A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens., PMID:31758400
β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells., PMID:31661467
Expression of the Voltage-Gated Potassium Channel Kv1.3 in Lesional Skin from Patients with Cutaneous T-Cell Lymphoma and Benign Dermatitis., PMID:31536992
Triple-Colocalization Approach to Assess Traffic Patterns and Their Modulation., PMID:31432482
Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke., PMID:31153377
KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis., PMID:30612588
Sex- and Development-Dependent Responses of Rat Microglia to Pro- and Anti-inflammatory Stimulation., PMID:30524242
Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex., PMID:30317390
Long noncoding RNA kcna3 inhibits the progression of colorectal carcinoma through down-regulating YAP1 expression., PMID:30099342
Discovery and development of differentially methylated regions in human papillomavirus-related oropharyngeal squamous cell carcinoma., PMID:30070359
Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis., PMID:29574670
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog., PMID:28389388
For research use only. Not for human or drug use.
