Catalog No.
YHH46701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr697-Gln1030
Predicted molecular weight
41.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q2M1P5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIF7, Kinesin-like protein KIF7
Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking., PMID:40073114
Construction of a novel copper-induced-cell-death-related gene signature for prognosis in colon cancer, with focus on KIF7., PMID:39695482
Expanding the Phenotypic Spectrum of Pathogenic KIAA0586 Variants: From Joubert Syndrome to Hydrolethalus Syndrome., PMID:39063141
P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression., PMID:38909089
Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I., PMID:38456964
Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk., PMID:37958793
Molecular investigation in individuals with orofacial clefts and microphthalmia-anophthalmia-coloboma spectrum., PMID:37932364
Cytoskeletal Keratins Are Overexpressed in a Zebrafish Model of Idiopathic Scoliosis., PMID:37239418
Proteomics identifies differentially expressed proteins in glioblastoma U87 cells treated with hederagenin., PMID:37120556
Clinical and genetic spectrum from a prototype of ciliopathy: Joubert syndrome., PMID:36580738
A transgenic zebrafish for in vivo visualization of cilia., PMID:35946311
Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions., PMID:35725768
Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia., PMID:34981518
Molecular Bases of Human Malformation Syndromes Involving the SHH Pathway: GLIA/R Balance and Cardinal Phenotypes., PMID:34884862
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding., PMID:34705483
Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development., PMID:34644112
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7., PMID:34114033
Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish., PMID:33382518
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7., PMID:32945133
Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing., PMID:32738303
Role of cilia in the pathogenesis of congenital heart disease., PMID:32418658
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer., PMID:32322170
Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome with ocular coloboma, pituitary malformation and growth hormone deficiency: a case report and literature review., PMID:32164589
Whole genome sequencing unveils genetic heterogeneity in optic nerve hypoplasia., PMID:32040484
Low expression of KIF7 indicates poor prognosis in epithelial ovarian cancer., PMID:31658044
Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7., PMID:31031197
Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice., PMID:30445565
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer., PMID:29874589
Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7., PMID:29351996
Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling., PMID:29321670
The role of the Hedgehog signaling pathway in cancer: A comprehensive review., PMID:29274272
Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase., PMID:29121065
ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5., PMID:28596487
The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus., PMID:28445929
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins., PMID:28444310
Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos., PMID:28390800
Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms., PMID:28341548
Recognition and characterization of Erythropoietin binding-proteins in the brain of mice., PMID:27803781
Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations., PMID:27485312
Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination., PMID:27195754
T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number., PMID:27046536
A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population., PMID:26602496
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms., PMID:26439735
MOLAR TOOTH SIGN AND ACROCALLOSAL SYNDROME--A REPORT ON A POLISH FAMILY AND REVIEW OF KIF7 SYNDROMOLOGY., PMID:26349186
Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome., PMID:26174511
Apparent Usher Syndrome Caused by the Combination of BBS1-Associated Retinitis Pigmentosa and SLC26A4-Associated Deafness., PMID:26022370
Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia., PMID:25921351
A novel KIF7 mutation in two affected siblings with acrocallosal syndrome., PMID:25714560
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5., PMID:25644602
For research use only. Not for human or drug use.
