Catalog No.
YHG90701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg45-Glu367
Predicted molecular weight
38.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14807
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kinesin-like DNA-binding protein, Kinesin-like protein KIF22, Kinesin-like protein 4, KID, KIF22, KNSL4
Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus)., PMID:40412113
Identification of Novel Biomarkers Related to Vesicle Trafficking in Alzheimer's Disease Using Bioinformatics Approaches., PMID:40338387
KIF22 promotes the proliferation and immune escape of endometrial cancer cells by activating the STAT3/PDL1 pathway., PMID:40326230
TFDP1 transcriptionally activates KIF22 to enhance aggressiveness and stemness in endometrial cancer: implications for prognosis and targeted therapy., PMID:39672972
Metformin Prevents Tumor Cell Growth and Invasion of Human Hormone Receptor-Positive Breast Cancer (HR+ BC) Cells via FOXA1 Inhibition., PMID:39000600
KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway., PMID:38713252
Identification of kinesin family member (KIF22) homozygous variants in spondyloepimetaphyseal dysplasia with joint laxity, lepdodactylic type and demonstration of proteoglycan biosynthesis impairment., PMID:38477767
KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling., PMID:37944197
[Retracted] KIF22 promotes bladder cancer progression by activating the expression of CDCA3., PMID:37615186
Spondyloepimetaphyseal dysplasia with joint laxity type 2: Aggregating the literature and reporting on the life of a 66-year-old man., PMID:37226647
Bioinformatics analysis: relationship between adrenocortical carcinoma and KIFs., PMID:36572958
Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach., PMID:36550548
Blood Transcriptome Analysis of Beef Cow with Different Parity Revealed Candidate Genes and Gene Networks Regulating the Postpartum Diseases., PMID:36140838
Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation., PMID:35730929
Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts., PMID:35715439
Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary., PMID:35628146
KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis., PMID:35578724
GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling., PMID:35436989
NUSAP1 Could be a Potential Target for Preventing NAFLD Progression to Liver Cancer., PMID:35431924
Quantifying Changes in Chromosome Position to Assess Chromokinesin Activity., PMID:34972951
KIF22 promotes bladder cancer progression by activating the expression of CDCA3., PMID:34633053
Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis., PMID:34472493
Establishment of myoblast cell line and identification of key genes regulating myoblast differentiation in a marine teleost, Sebastes schlegelii., PMID:34352298
Identification of Key Genes Involved in Pancreatic Ductal Adenocarcinoma with Diabetes Mellitus Based on Gene Expression Profiling Analysis., PMID:34257566
KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122., PMID:34150005
Potential prognostic markers and significant lncRNA-mRNA co-expression pairs in laryngeal squamous cell carcinoma., PMID:34131588
Comparative genomics of the coconut crab and other decapod crustaceans: exploring the molecular basis of terrestrial adaptation., PMID:33931033
Expression of Genes in the 16p11.2 Locus during Development of the Human Fetal Cerebral Cortex., PMID:33825894
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer., PMID:32322170
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways., PMID:32187050
Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma., PMID:32090103
Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Colon Cancer., PMID:31657617
Induction of a Spindle-Assembly-Competent M Phase in Xenopus Egg Extracts., PMID:30930041
Delayed Chromosome Alignment to the Spindle Equator Increases the Rate of Chromosome Missegregation in Cancer Cell Lines., PMID:30597919
High Expression of KIF22/Kinesin-Like DNA Binding Protein (Kid) as a Poor Prognostic Factor in Prostate Cancer Patients., PMID:30427826
Detecting genetic modifiers of spondyloepimetaphyseal dysplasia with joint laxity in the Caucasian Afrikaner community., PMID:30358852
Chromokinesins., PMID:30300593
KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation., PMID:29382784
The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase., PMID:27550518
Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water., PMID:28959563
Drosophila Homolog of Human KIF22 at the Autism-Linked 16p11.2 Loci Influences Synaptic Connectivity at Larval Neuromuscular Junctions., PMID:26924931
NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force., PMID:26839278
A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene., PMID:26669664
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules., PMID:25743205
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces., PMID:25383660
Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells., PMID:25381824
Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type: longitudinal observation of radiographic findings in a child heterozygous for a KIF22 mutation., PMID:25256152
Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions., PMID:24857737
Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression., PMID:24626146
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype., PMID:23665482
For research use only. Not for human or drug use.
