Catalog No.
YHH26001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu1467-Ala1823
Predicted molecular weight
41.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16363
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Laminin-8 subunit alpha, Laminin-9 subunit alpha, Laminin-14 subunit alpha, Laminin subunit alpha-4, LAMA4, laminin 8, laminin 411, laminin 9, laminin 421, laminin 14, laminin 423
Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based Approach to Tumor Microenvironment Remodeling., PMID:40507957
ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling., PMID:40462244
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence., PMID:40289085
METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma., PMID:40251670
Deciphering the role of lncRNA-mediated ceRNA network in disuse osteoporosis: insights from bone marrow mesenchymal stem cells under simulated microgravity., PMID:40248073
The potential key genes within focal adhesion that regulate mesenchymal stem cells osteogenesis or adipogenesis in microgravity related disuse osteoporosis: an integrated analysis., PMID:40130165
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes., PMID:39915484
Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4., PMID:39833606
A potential pathogenic mutation of LAMA4 in a Chinese family with dilated cardiomyopathy and conduction system disease., PMID:39686469
Integrated analysis and systematic characterization of the regulatory network for human germline development., PMID:39571792
FOXP2 overexpression upregulates LAMA4 expression and thereby alleviates preeclampsia by regulating trophoblast behavior., PMID:39487340
New Anti-Angiogenic Therapy for Glioblastoma With the Anti-Depressant Sertraline., PMID:39440923
Integrated ubiquitomics characterization of hepatocellular carcinomas., PMID:39348425
Anti-Laminin β4 IgG Drives Tissue Damage in Anti-p200 Pemphigoid and Shows Interactions with Laminin α3 and γ1/2 Chains., PMID:39320300
Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma., PMID:39039002
Extracellular Matrix Protein Signatures of the Outer and Inner Zones of the Rat Adrenal Cortex., PMID:39018382
Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosis., PMID:38775886
Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia., PMID:38541736
Identification of microRNA-mRNA Regulatory Networks with Therapeutic Values in Alzheimer's Disease by Bioinformatics Analysis., PMID:38427479
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration., PMID:37694778
Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation., PMID:37434153
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication., PMID:37311512
FRC transplantation restores lymph node conduit defects in laminin α4-deficient mice., PMID:37092548
Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells., PMID:36996622
[Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases]., PMID:36861161
Effects of semaglutide on vascular structure and proteomics in high-fat diet-induced obese mice., PMID:36419767
Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study., PMID:36378498
A Case Report of Genetic Cascade Screening in Dilated Cardiomyopathy: A Perspective for Preventive Cardiology., PMID:36317039
Single-Cell Transcriptomics of Endothelial Cells in Upper and Lower Human Esophageal Squamous Cell Carcinoma., PMID:36290884
Secretomics Alterations and Astrocyte Dysfunction in Human iPSC of Leukoencephalopathy with Vanishing White Matter., PMID:36198922
Adipose extracellular matrix deposition is an indicator of obesity and metabolic disorders., PMID:36162565
Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii)., PMID:36142434
Laminin-α4 Negatively Regulates Adipocyte Beiging Through the Suppression of AMPKα in Male Mice., PMID:36124842
Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation., PMID:36070364
Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors., PMID:35965583
Genetic Profile of Left Ventricular Noncompaction Cardiomyopathy in Children-A Single Reference Center Experience., PMID:35893073
Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4., PMID:35775481
Identification of genetic polymorphisms in unexplained recurrent spontaneous abortion based on whole exome sequencing., PMID:35722368
Peroxynitrous acid-modified extracellular matrix alters gene and protein expression in human coronary artery smooth muscle cells and induces a pro-inflammatory phenotype., PMID:35526806
Rare and potential pathogenic mutations of LMNA and LAMA4 associated with familial arrhythmogenic right ventricular cardiomyopathy/dysplasia with right ventricular heart failure, cerebral thromboembolism and hereditary electrocardiogram abnormality., PMID:35526016
High-Fat-Diet-Induced Extracellular Matrix Deposition Regulates Integrin-FAK Signals in Adipose Tissue to Promote Obesity., PMID:35106921
HIF-1α aggravates pathologic myopia through the miR-150-5p/LAMA4/p38 MAPK signaling axis., PMID:35034256
Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression., PMID:34958665
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4., PMID:34575887
Identification of potential genes related to breast cancer brain metastasis in breast cancer patients., PMID:34541602
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer., PMID:34512203
Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer., PMID:34414238
Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity., PMID:34394003
Exploring the changes of brain immune microenvironment in Alzheimer's disease based on PANDA algorithm combined with blood brain barrier injury-related genes., PMID:33865224
Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma., PMID:37034513
For research use only. Not for human or drug use.
