Catalog No.
YHK72201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met51-Thr144
Predicted molecular weight
24.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P0J0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 protein, CI-B16.6, Cell death regulatory protein GRIM-19, NADH-ubiquinone oxidoreductase B16.6 subunit, GRIM-19, Complex I-B16.6, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, GRIM19, NDUFA13
Complex Metabolomic Changes in a Combined Defect of Glycosylation and Oxidative Phosphorylation in a Patient with Pathogenic Variants in PGM1 and NDUFA13., PMID:40358162
MIA40 suppresses cell death induced by apoptosis-inducing factor 1., PMID:40055465
Biallelic NDUFA13 variants lead to a neurodevelopmental phenotype with gradual neurological impairment., PMID:39963288
Identification of a novel pathogenic gene, NDUFA3, in Leigh Syndrome through whole exome sequencing., PMID:39661167
SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress., PMID:39158709
Deregulation of oxidative phosphorylation pathways in embryos derived in vitro from prepubertal and pubertal heifers based on whole-transcriptome sequencing., PMID:38914933
Low Expression of GRIM-19 Correlates with Poor Prognosis in Patients with Upper Urinary Tract Urothelial Carcinoma., PMID:38847244
[Adeno-associated virus-mediated hepatocyte-specific NDUFA13 overexpression protects against CCl4-induced liver fibrosis in mice by inhibiting hepatic NLRP3 activation]., PMID:38501404
GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS., PMID:38360073
GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†., PMID:38206868
Mef2c regulates bone mass through Sost-dependent and -independent mechanisms., PMID:38042445
Chemical and Genetic Modulation of Complex I of the Electron Transport Chain Enhances the Biotherapeutic Protein Production Capacity of CHO Cells., PMID:37998396
Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma., PMID:37955686
A novel proteomic-based model for predicting colorectal cancer with Schistosoma japonicum co-infection by integrated bioinformatics analysis and machine learning., PMID:37904220
Abnormal methylation in the NDUFA13 gene promoter of breast cancer cells breaks the cooperative DNA recognition by transcription factors., PMID:37529293
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis., PMID:36990300
Identification of m7G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure., PMID:36782329
Hippocampal RNA sequencing in mice selectively bred for high and low activity., PMID:36514243
Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion., PMID:36387896
Decreased expression of GRIM-19 induces autophagy through the AMPK/ULK1 signaling pathway during adenomyosis†., PMID:35908189
GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation., PMID:34907600
GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis., PMID:34906422
Structural exploration with AlphaFold2-generated STAT3α structure reveals selective elements in STAT3α-GRIM-19 interactions involved in negative regulation., PMID:34848745
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis., PMID:34461110
[Mechanism of hepatocyte mitochondrial NDUFA13 deficiency-induced liver fibrogenesis: the role of abnormal hepatic stellate cell activation]., PMID:33963711
Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2., PMID:33650635
[Pathogenic role of NDUFA13 inactivation in spontaneous hepatitis in mice and the mechanism]., PMID:33509753
LGR5 induces β-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma., PMID:33249719
Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway., PMID:33174032
Interaction of M2 macrophages and endometrial cells induces downregulation of GRIM-19 in endometria of adenomyosis., PMID:32896475
Novel NDUFA13 Mutations Associated with OXPHOS Deficiency and Leigh Syndrome: A Second Family Report., PMID:32722639
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks., PMID:32444848
STAT3 inhibition induced temozolomide-resistant glioblastoma apoptosis via triggering mitochondrial STAT3 translocation and respiratory chain dysfunction., PMID:32165236
Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b., PMID:31531888
Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications., PMID:31382833
GRIM-19 repressed hypoxia-induced invasion and EMT of colorectal cancer by repressing autophagy through inactivation of STAT3/HIF-1α signaling axis., PMID:30537081
Inhibition of miR-423-5p suppressed prostate cancer through targeting GRIM-19., PMID:30415005
Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer., PMID:30272302
Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes., PMID:30032298
Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization., PMID:30005830
The effect of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) on STAT3-induced gene expression in renal carcinoma., PMID:29961871
Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis., PMID:29741731
The Role of Promyelocytic Leukemia Protein in Steatosis-Associated Hepatic Tumors Related to Chronic Hepatitis B virus Infection., PMID:29684791
Grim-19 expressed by recombinant adenovirus for esophageal neoplasm target therapy., PMID:29488605
Retinoid interferon-induced mortality19 (GRIM19) inhibits proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes., PMID:29306209
Prognostic value of GRIM-19, NF-κB and IKK2 in patients with high-grade serous ovarian cancer., PMID:29254797
Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation., PMID:29106036
Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3., PMID:29078279
miR-6743-5p, as a direct upstream regulator of GRIM-19, enhances proliferation and suppresses apoptosis in glioma cells., PMID:29074558
Molecular profiles of oxyphilic and chief cell parathyroid adenoma., PMID:28986304
For research use only. Not for human or drug use.
