Catalog No.
YHG49301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala325
Predicted molecular weight
38.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13347
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation initiation factor 3 subunit I, TGF-beta receptor-interacting protein 1, TRIP-1, eIF3i, EIF3S2, TRIP1, eIF-3-beta, eIF3 p36, EIF3I, Eukaryotic translation initiation factor 3 subunit 2
40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion., PMID:39803544
Specific Activation of the Expression of Growth Factor Genes in Expi293F Human Cells Using CRISPR/Cas9-SAM Technology Increases Their Proliferation., PMID:39539522
METTL3-mediated m6A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I., PMID:38374407
Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production., PMID:37697064
circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer., PMID:37689715
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation., PMID:37611825
Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors., PMID:37216290
Insights into the Structure and Function of TRIP-1, a Newly Identified Member in Calcified Tissues., PMID:36979349
Histone Deacetylase 1 Expression and Regulatory Network in Lung Adenocarcinoma Based on Data Mining and Implications for Targeted Treatment., PMID:36644230
Molecular and Structural Characterization of Lenalidomide-Mediated Sequestration of eIF3i., PMID:36325969
Circ-EIF3I facilitates proliferation, migration, and invasion of lung cancer via regulating the activity of Wnt/β-catenin pathway through the miR-1253/NOVA2 axis., PMID:36193788
Liver cancer cells with nuclear MET overexpression release translation regulatory protein-enriched extracellular vesicles exhibit metastasis promoting activity., PMID:38939527
A Broad m6A Modification Landscape in Inflammatory Bowel Disease., PMID:35127705
Development of Photolenalidomide for Cellular Target Identification., PMID:34978798
Large-scale movement of eIF3 domains during translation initiation modulate start codon selection., PMID:34648019
PD-L1 Triggered by Binding eIF3I Contributes to the Amelioration of Diabetes-Associated Wound Healing Defects by Regulating IRS4., PMID:34293353
A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy., PMID:33807050
Identification of hub ubiquitin ligase genes affecting Alzheimer's disease by analyzing transcriptome data from multiple brain regions., PMID:33754896
Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway., PMID:33526846
EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle., PMID:33508274
eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis., PMID:33301799
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability., PMID:32867821
EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability., PMID:32269044
Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility., PMID:32170005
Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis., PMID:32061967
Cancer Targeted Gene Therapy for Inhibition of Melanoma Lung Metastasis with eIF3i shRNA Loaded Liposomes., PMID:31765158
Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway., PMID:31376806
Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry., PMID:31370342
The function and clinical significance of eIF3 in cancer., PMID:29908282
TRIP-1 in the extracellular matrix promotes nucleation of calcium phosphate polymorphs., PMID:29745814
Structure of a human cap-dependent 48S translation pre-initiation complex., PMID:29401259
EIF3i affects vesicular stomatitis virus growth by interacting with matrix protein., PMID:29173589
eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation., PMID:28193911
Identification of potential molecular associations between chikungunya virus non-structural protein 2 and human host proteins., PMID:28105853
TGF beta receptor II interacting protein-1, an intracellular protein has an extracellular role as a modulator of matrix mineralization., PMID:27883077
eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition., PMID:27373335
The Rice Eukaryotic Translation Initiation Factor 3 Subunit f (OseIF3f) Is Involved in Microgametogenesis., PMID:27200010
Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity., PMID:26420881
Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts., PMID:25785348
Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma., PMID:25609201
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis., PMID:25539953
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis., PMID:25147179
Penta-O-galloyl-β-D-glucose suppresses EGF-induced eIF3i expression through inhibition of the PI3K/AKT/mTOR pathway in prostate cancer cells., PMID:25123845
MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer., PMID:24558198
TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation., PMID:24528651
The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h., PMID:24320561
Genetic cell ablation., PMID:24318834
EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation., PMID:24056964
Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex., PMID:23921387
Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma., PMID:23460382
For research use only. Not for human or drug use.
