Catalog No.
YHH27201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln71-Lys421
Predicted molecular weight
42.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16515
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BNaC1, ACCN, ACCN1, Mammalian degenerin homolog, Acid-sensing ion channel 2, BNAC1, MDEG, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, ASIC2, Brain sodium channel 1, Amiloride-sensitive cation channel neuronal 1, BNC1
The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer., PMID:40437028
Ion-Channel Proteins in the Prepubertal Bitch Reproductive System: The Immunolocalization of ASIC2, ASIC4, and PIEZO2., PMID:40362625
ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide., PMID:40305197
Mice lacking acid-sensing ion channel 2 in the medial prefrontal cortex exhibit social dominance., PMID:39453995
Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome., PMID:39224121
Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization., PMID:39016176
Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury., PMID:38660789
Acid-Sensing Ion Channels' Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body., PMID:38138991
Exploring somatosensory innervation of the human lip: A focus on the vermilion., PMID:37741584
The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment., PMID:36951012
Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse., PMID:36793786
Therapeutic effects of a soluble guanylate cyclase activator, BAY 60-2770, on lower urinary tract dysfunction in mice with spinal cord injury., PMID:35952343
Long Non-coding RNA and mRNA Co-expression Network Reveals Novel Players in Pleomorphic Xanthoastrocytoma., PMID:35674862
Recent Advances in Acid-sensitive Ion Channels in Central Nervous System Diseases., PMID:35466865
A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats., PMID:35447498
βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole., PMID:35285274
Acid-Sensing Ion Channel 2: Function and Modulation., PMID:35207035
Sa12b Improves Biological Activity of Human Degenerative Nucleus Pulposus Mesenchymal Stem Cells in a Severe Acid Environment by Inhibiting Acid-Sensitive Ion Channels., PMID:35178382
Comparative description of the mRNA expression profile of Na+ /K+ -ATPase isoforms in adult mouse nervous system., PMID:34415061
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2., PMID:34321072
ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors., PMID:34215968
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors., PMID:34199609
A variant of ASIC2 mediates sodium retention in nephrotic syndrome., PMID:34166227
Acid Sensing Ion Channel 2a Is Reduced in the Reduced Uterine Perfusion Pressure Mouse Model and Increases Seizure Susceptibility in Pregnant Mice., PMID:34066660
Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model., PMID:33969698
Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1., PMID:33888605
Nutrigenomics reveals potential genetic underpinning of diverse taste preference of Chinese men., PMID:33843022
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration., PMID:33824228
RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain., PMID:33724568
Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rats., PMID:33677419
Locus Coeruleus Acid-Sensing Ion Channels Modulate Sleep-Wakefulness and State Transition from NREM to REM Sleep in the Rat., PMID:33638800
Cell-Type-Specific Expression Pattern of Proton-Sensing Receptors and Channels in Pituitary Gland., PMID:33098866
The juxta-oral organ of Chievitz (organum yuxtaorale) updated: Embryology, anatomy, function and pathology., PMID:32810612
Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes., PMID:32575443
Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels., PMID:31952079
Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles., PMID:31752671
Therapeutic effects of inhibition of brain-derived neurotrophic factor on voiding dysfunction in mice with spinal cord injury., PMID:31566429
High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures., PMID:31531354
The critical role of calcineurin/NFAT (C/N) pathways and effective antitumor prospect for colorectal cancers., PMID:31489709
Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus., PMID:31451914
Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)., PMID:31443477
Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension., PMID:31169471
A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels., PMID:31045491
Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus., PMID:31010811
Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill., PMID:30772482
Acid sensing ion channel 2: A new potential player in the pathophysiology of multiple sclerosis., PMID:30549327
Abnormal response of costal chondrocytes to acidosis in patients with chest wall deformity., PMID:30485799
High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women., PMID:30343302
Activation of rat masticatory muscle afferent fibres by acidic pH., PMID:29848210
Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a)., PMID:29739981
For research use only. Not for human or drug use.
