Catalog No.
YHK71201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly529-Met941
Predicted molecular weight
50.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZ08
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Aminopeptidase PILS, ARTS1, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, PILS-AP, Endoplasmic reticulum aminopeptidase 1, ARTS-1, A-LAP, Puromycin-insensitive leucyl-specific aminopeptidase, APPILS, ERAP1, KIAA0525, Adipocyte-derived leucine aminopeptidase
APN3 Acts as a Functional Receptor of Bacillus thuringiensis Cry1Ac in Grapholita molesta., PMID:40405385
Mendelian randomization analysis identifies ERAP1 and IL23R as potential drug targets for ankylosing spondylitis., PMID:40349828
ERAP1 Activity Modulates the Immunopeptidome but Also Affects the Proteome, Metabolism, and Stress Responses in Cancer Cells., PMID:40189142
Deleterious KOs in the HLA Class I Antigen Processing and Presentation Machinery Induce Distinct Changes in the Immunopeptidome., PMID:40113210
Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis., PMID:39937552
The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis., PMID:39910453
Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population., PMID:39906739
Potential Therapeutic drug Targets for Hypertension Identified using Proteomics and Mendelian Randomization., PMID:39844355
Defining a genetic background for bamboo spine and axial spondyloarthritis., PMID:39828050
Effective Reduction of Transgene-Specific Immune Response With rAAV Vectors Co-Expressing miRNA-UL112-5p or ERAP1 shRNA., PMID:39823241
The association of HLA-DRB1 allele group but not HLA-B or ERAP1-rs7063 gene polymorphisms with atopic dermatitis., PMID:39808847
Identifying prioritization of therapeutic targets for ankylosing spondylitis: a multi-omics Mendelian randomization study., PMID:39707330
Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis., PMID:39676709
Genomes of two invasive Adelges species (hemlock woolly adelgid and pineapple gall adelgid) enable characterization of nicotinic acetylcholine receptors., PMID:39605547
ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia., PMID:39570751
Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint., PMID:39561763
Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection., PMID:39533856
Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties., PMID:39493758
Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma., PMID:39438988
First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease., PMID:39369482
TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44., PMID:39348940
Investigating potential novel therapeutic targets and biomarkers for ankylosing spondylitis using plasma protein screening., PMID:39185422
Biology of HLA class I associated inflammatory diseases., PMID:39085016
Association of Endoplasmic Reticulum Aminopeptidase 1 Gene Polymorphism with Susceptibility and Severity of Axial Spondyloarthritis in Egyptian Population: A Single-center Case-Control Study., PMID:39034571
Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation., PMID:39024058
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights., PMID:39011823
The expression of ERAP1 is favorable for the prognosis and immunotherapy in colorectal cancer: a study based on the bioinformatic and immunohistochemical analysis., PMID:39009862
Cross-Phenotype GWAS Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis., PMID:39006426
[Relationship between maternal and fetal ERAP-1 gene polymorphism and pre-eclampsia]., PMID:38951078
Differential response of placental cells to high D-glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras-related protein RAB-7A., PMID:38938672
ERAMER: A novel in silico tool for prediction of ERAP1 enzyme trimming., PMID:38925438
Significant Correlation Between Cutaneous Abundance of Streptococcus and Psoriasis Severity in Patients with FBXL19 Gene Variants., PMID:38898675
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers., PMID:38835753
ERAP1 and ERAP2 gene variants as potential clinical biomarkers of anti-interleukin-17A response in psoriasis vulgaris., PMID:38616723
Novel genetic variants of HLA gene associated with Thai Behcet's disease (BD) patients using next generation sequencing technology., PMID:38575661
Role of endoplasmic reticulum aminopeptidase-1 gene polymorphism (rs13167972) in occurrence susceptibility of ankylosing spondylitis in a sample of Iraqi male patients., PMID:38551779
The Role of Aminopeptidase ERAP1 in Human Pathology-A Review., PMID:38534723
Identification of immunological patterns characterizing immune-related psoriasis reactions in oncological patients in therapy with anti-PD-1 checkpoint inhibitors., PMID:38495872
"Zero" Intrinsic Fluorescence Sensing-Platforms Enable Ultrasensitive Whole Blood Diagnosis and In Vivo Imaging., PMID:38409519
Association of a single nucleotide polymorphism (rs27434) in the ERAP1 gene with plural tissue weight., PMID:38342012
Sequence of Events in the Pathogenesis of Axial Spondyloarthritis: A Current Review-2023 SPARTAN Meeting Proceedings., PMID:38324125
ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study., PMID:38314748
PIK3CA regulates development of diabetes retinopathy through the PI3K/Akt/mTOR pathway., PMID:38194422
Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy., PMID:38177179
Serum biomarkers and their relationship to axial spondyloarthritis associated with inflammatory bowel diseases., PMID:38168574
Human motor neurons derived from induced pluripotent stem cells are susceptible to SARS-CoV-2 infection., PMID:38116398
[The role of HLA-B27 in the pathogenesis and diagnosis of axial spondyloarthritis : 50 years after discovery of the strong genetic association]., PMID:38112753
Behçet's Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade., PMID:38003572
A large meta-analysis identifies genes associated with anterior uveitis., PMID:37949852
Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities., PMID:37858978
For research use only. Not for human or drug use.
