Catalog No.
YHK71001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser39-Gly230
Predicted molecular weight
24.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92888
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p115-RhoGEF, p115RhoGEF, 115 kDa guanine nucleotide exchange factor, Sub1.5, Rho guanine nucleotide exchange factor 1, ARHGEF1
VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution., PMID:40501792
SNP-associated differential methylation in ARHGEF38: insights into genetic-epigenetic interactions., PMID:40444651
YAP controls cell migration and invasion through a Rho GTPase switch., PMID:40424361
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion., PMID:40421714
[RGL1 overexpression promotes metastasis of colorectal cancer by upregulating motile focal adhesion assembly via activating the CDC42/RAC1 complex]., PMID:40415435
The role of RAC1 in resistance to targeted therapies in cancer., PMID:40396280
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias., PMID:40366302
A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis., PMID:40341916
METTL3 Promotes Cutaneous T-Cell Lymphoma Progression by Regulating ARHGEF12 Expression., PMID:40332203
The Rho GEF Trio functions in contact inhibition of locomotion of neural crest cells by interacting with Ptk7., PMID:40326503
Rho-GTPases subfamily: cellular defectors orchestrating viral infection., PMID:40316910
VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7., PMID:40303312
Polarized subcellular activation of Rho proteins by specific ROPGEFs drives pollen germination in Arabidopsis thaliana., PMID:40258071
Activation of a Potassium Channel Mutation That Causes Spinocerebellar Ataxia Promotes Aggregation of the RhoGEF Domain-Containing Protein Plekhg4., PMID:40249242
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages., PMID:40216763
Landscape of lncRNAs expressed in Mexican patients with triple‑negative breast cancer., PMID:40211710
Modeling bone marrow microenvironment and hematopoietic dysregulation in Gaucher disease through VavCre mediated Gba deletion., PMID:40197748
Current and future of targeted therapies against BCR::ABL kinases., PMID:40189648
CDC42 Regulatory Patterns Related To Inflammatory Bowel Disease and Hyperglycemia., PMID:40183002
Three Rho of Plant (ROP)-GTPase regulatory proteins control ROP-mediated alkaloid biosynthesis in Catharanthus roseus., PMID:40173382
Effects of Rho inhibitors on membrane depolarization-induced contraction of male rat caudal arterial smooth muscle., PMID:40165590
The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning., PMID:40164947
Establishment and functional studies of a model of cardiomyopathy with cardiomyocyte-specific conditional knockout of Arhgef18., PMID:40159883
GEF-H1 drives breast cancer cells to tumor progression., PMID:40154811
Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization., PMID:40138406
PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly., PMID:40126693
Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia., PMID:40114373
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation., PMID:40082605
Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy., PMID:40066567
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity., PMID:40044852
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner., PMID:40000966
ARHGEF18 is a flow-responsive exchange factor controlling endothelial tight junctions and vascular leakage., PMID:39977269
Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation., PMID:39923106
Critical Role of Rho Guanine Nucleotide Exchange Factor 4 in Brain Function., PMID:39920439
ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression., PMID:39903211
Loss of Arhgap39 facilitates cell migration and invasion in murine hepatocellular cancer cells., PMID:39866228
The juxtamembrane sequence of small ankyrin 1 mediates the binding of its cytoplasmic domain to SERCA1 and is required for inhibitory activity., PMID:39863105
Distribution of BCR::ABL1 Transcript Types and Response to Therapy in Pediatric Patients with Chronic Myeloid Leukemia., PMID:39863016
The MCPH7 Gene Product STIL Is Essential for Dendritic Spine Formation., PMID:39851490
Missense variants at the p.Arg225 residue in ARHGEF40 identified in individuals with multiple congenital anomalies and developmental delay., PMID:39838643
Dedicator of cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions., PMID:39836640
Identification of ARHGEF11 (PDZ-RhoGEF) as an in vivo regulator of synapses and cognition., PMID:39835891
Impact of Recent Translational and Therapeutic Developments on Clinical Course of BCR::ABL1-Positive and -Negative Myeloproliferative Neoplasms., PMID:39825826
The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis., PMID:39820335
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis., PMID:39804820
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression., PMID:39747410
Cell migration signaling through the EGFR-VAV2-Rac1 pathway is sustained in endosomes., PMID:39744818
A Review of Clonal Relationships in Myeloproliferative Neoplasms With Co-Mutations of JAK2, CALR or MPL and BCR::ABL1., PMID:39743410
Mesenchymal cell contractility regulates villus morphogenesis and intestinal architecture., PMID:39708944
Phosphorylation of Ephexin4 at Ser-41 contributes to chromosome alignment via RhoG activation in cell division., PMID:39675713
For research use only. Not for human or drug use.
