Catalog No.
YHA06301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr422
Predicted molecular weight
49.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00231
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5, 26S proteasome non-ATPase regulatory subunit 11, PSMD11
Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer's Disease Mice., PMID:40236239
PSMD11 and PSMD14 may serve as novel biomarkers for the prognosis of pancreatic ductal adenocarcinoma., PMID:40182048
Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses., PMID:40033250
Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1., PMID:39850819
Prognostic value and potential biological function of PMSD11 in lung adenocarcinoma., PMID:39678883
SITP: A single cell bioinformatics analysis flow captures proteasome markers in the development of breast cancer., PMID:39550019
Promoting proteostasis by cAMP/PKA and cGMP/PKG., PMID:39477759
PSMD11 promotes the proliferation of hepatocellular carcinoma by regulating the ubiquitination degradation of CDK4., PMID:38944255
PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response., PMID:38866022
Identification of PSMD11 as a novel cuproptosis- and immune-related prognostic biomarker promoting lung adenocarcinoma progression., PMID:38859698
Identification of Genes Hub Associated with Triple-Negative Breast Cancer and Cannabidiol Analogs Potential Inhibitory Agents: An In-silico Study., PMID:38809637
Genetic blockade of the activation of 26S proteasomes by PKA is well tolerated by mice at baseline., PMID:38764549
IBPGNET: lung adenocarcinoma recurrence prediction based on neural network interpretability., PMID:38557672
Cisplatin Disrupts Proteasome Bounce-Back Effect through Suppressing ZEB1/Nfe2l1 in Cholangiocarcinoma., PMID:38538281
Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach., PMID:38463626
S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy., PMID:37641975
An integrative analysis reveals the prognostic value and potential functions of PSMD11 in hepatocellular carcinoma., PMID:37212487
PSMD11 modulates circadian clock function through PER and CRY nuclear translocation., PMID:36961772
"From molecular to clinic": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib., PMID:36936942
Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens)., PMID:36277216
Screening of key biomarkers in osteoporosis: Evidence from bioinformatic analysis., PMID:36219533
Label-free Quantitative Proteomic Analysis of Ascorbic Acid-induced Differentially Expressed Osteoblast-related Proteins in Dental Pulp Stem Cells from Deciduous and Permanent Teeth., PMID:35762553
A Data Science Approach for the Identification of Molecular Signatures of Aggressive Cancers., PMID:35565454
The Prognostic Significance of Proteasome 26S Subunit, Non-ATPase (PSMD) Genes for Bladder Urothelial Carcinoma Patients., PMID:34992336
Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance., PMID:34206811
Prognostic Value and Molecular Mechanisms of Proteasome 26S Subunit, Non-ATPase Family Genes for Pancreatic Ductal Adenocarcinoma Patients after Pancreaticoduodenectomy., PMID:33525943
Generation and identification of a conditional knockout allele for the PSMD11 gene in mice., PMID:33517884
Long noncoding RNA Nespas inhibits apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway., PMID:33212147
The Cardiac Syndecan-2 Interactome., PMID:32984315
Relationship between the Expression Level of PSMD11 and Other Proteasome Proteins with the Activity of Ricin and Viscumin., PMID:32894464
PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression., PMID:32663515
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models., PMID:32450067
Discovery of a Small Molecule Probe of Rpn-6, an Essential Subunit of the 26S Proteasome., PMID:31877015
MicroRNA-451 inhibits inflammation and proliferation of glomerular mesangial cells through down-regulating PSMD11 and NF-κB p65., PMID:31652441
Identification of key candidate genes involved in melanoma metastasis., PMID:31173190
Altered proteasome function in right ventricular hypertrophy., PMID:31020333
Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes., PMID:30670769
Roasted Coffee Reduces β-Amyloid Production by Increasing Proteasomal β-Secretase Degradation in Human Neuroblastoma SH-SY5Y Cells., PMID:30144352
Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells., PMID:29665121
Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan., PMID:29457374
Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease., PMID:27857231
Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation., PMID:27291871
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins., PMID:26669444
Proteomic profiling identified multiple short-lived members of the central proteome as the direct targets of the addicted oncogenes in cancer cells., PMID:24105791
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11., PMID:22972301
Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes., PMID:20223764
Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase., PMID:19616115
Alterations in mRNA expression and protein products following spinal cord injury in humans., PMID:17218363
Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics., PMID:17004105
For research use only. Not for human or drug use.
