Catalog No.
YHK70901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg41-Ser327
Predicted molecular weight
34.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96MT3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
REST/NRSF-interacting LIM domain protein 1, RILP, PRICKLE1, Prickle-like protein 1
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins., PMID:40327382
Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice., PMID:39917256
Loss of Myostatin Affects m6A Modification but Not Semen Characteristics in Bull Spermatozoa., PMID:39859306
Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1., PMID:39753546
Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice., PMID:39679867
Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis., PMID:39314474
Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice., PMID:39211179
Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy., PMID:38315003
Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR., PMID:38309264
Prickle1-driven basement membrane deposition of the iPSC-derived embryoid bodies is separable from the establishment of apicobasal polarity., PMID:38185785
Rapid Regulation of Cardiomyocytes Adhesion on Substrates with Varied Modulus via Mechanical Cues., PMID:37956199
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis., PMID:37742487
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity., PMID:37589075
[Prickle planar cell polarity protein 1 involved in the pathogenesis of skeletal class Ⅲ malocclusion]., PMID:37550040
Long non-coding RNAs mediate the association between short-term PM2.5 exposure and circulating biomarkers of systemic inflammation., PMID:37541382
Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function., PMID:37440262
EZH2 activates Wnt/β-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate., PMID:37182601
Emerging roles of planar cell polarity proteins in glutamatergic synapse formation, maintenance and function in health and disease., PMID:36780134
Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules., PMID:36582832
Long noncoding RNA MEG3 inhibits oral squamous cell carcinoma progression via GATA3., PMID:36468944
Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium., PMID:36176272
AutoCaSc: Prioritizing candidate genes for neurodevelopmental disorders., PMID:35998261
Transcriptome analysis of peripheral blood mononuclear cells in patients with type 1 diabetes mellitus., PMID:35976509
The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins., PMID:35971817
Cell cortex regulation by the planar cell polarity protein Prickle1., PMID:35512799
USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components., PMID:35440748
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway., PMID:34642262
Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism., PMID:34597683
PRICKLE1 × FOCAD Interaction Revealed by Genome-Wide vQTL Analysis of Human Facial Traits., PMID:34434215
Chondrocyte Polarity During Endochondral Ossification Requires Protein-Protein Interactions Between Prickle1 and Dishevelled2/3., PMID:34423861
Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner., PMID:34331380
PRICKLE1 promotes gastric cancer metastasis by activating mTOR signaling., PMID:34150013
sFRP1 Expression Regulates Wnt Signaling in Chronic Myeloid Leukemia K562 Cells., PMID:34030621
PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia., PMID:34001134
Ontogenesis of the tear drainage system requires Prickle1-driven polarized basement membrane deposition., PMID:33144400
Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis., PMID:33141892
Transcriptional landscape of the embryonic chicken Müllerian duct., PMID:33008304
BIOCHIP mosaic for the diagnosis of autoimmune bullous diseases in Chinese patients., PMID:32969793
Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S., PMID:32764572
Identification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer., PMID:32537023
Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled., PMID:32392721
A detailed description of the phenotypic spectrum of North Sea Progressive Myoclonus Epilepsy in a large cohort of seventeen patients., PMID:32105965
The genomic and clinical landscape of fetal akinesia., PMID:31680123
Topologically correct central projections of tetrapod inner ear afferents require Fzd3., PMID:31311957
A very rare form of autosomal dominant progressive myoclonus epilepsy caused by a novel variant in the PRICKLE1 gene., PMID:31035234
ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer., PMID:30971775
Prickle1 is required for EMT and migration of zebrafish cranial neural crest., PMID:30721665
Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival., PMID:30702489
For research use only. Not for human or drug use.
