Catalog No.
YHE97301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp22-Met499
Predicted molecular weight
56.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53041
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PP-T, Protein phosphatase T, Serine/threonine-protein phosphatase 5, PPP5, PPT, PP5, PPP5C
PPP5C pathogenic variant identified: a potential key to gaining insight into developmental and epileptic encephalopathy?, PMID:40172746
Circadian clock-related genome-wide mendelian randomization identifies putatively genes for ulcerative colitis and its comorbidity., PMID:38302916
Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation., PMID:37377738
Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery., PMID:37054560
Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer., PMID:36012478
MiR-520a-5p/PPP5C regulation pattern is identified as the key to gemcitabine resistance in pancreatic cancer., PMID:35957917
Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay., PMID:35361529
Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer., PMID:34964699
PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation., PMID:34490876
MicroRNA-365b-3p represses the proliferation and promotes the apoptosis of non-small cell lung cancer cells by targeting PPP5C., PMID:33777212
The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer., PMID:33270085
Ubiquitin ligase CHAF1B induces cisplatin resistance in lung adenocarcinoma by promoting NCOR2 degradation., PMID:32508530
S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling., PMID:31916625
The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C., PMID:30679389
PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation., PMID:30254472
Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells in vitro., PMID:29805615
PP5 (PPP5C) is a phosphatase of Dvl2., PMID:29426949
Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis., PMID:29283027
Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells., PMID:28534961
Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct., PMID:27784696
Knockdown of protein phosphatase 5 (PPP5C) suppresses the growth of leukemic cell line U937., PMID:27755948
Knockdown of protein phosphatase 5 inhibits ovarian cancer growth in vitro., PMID:26870184
Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus., PMID:26196943
Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma., PMID:25796168
Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C)., PMID:25383722
Knockdown of PPP5C inhibits growth of hepatocellular carcinoma cells in vitro., PMID:25326185
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1., PMID:24371145
Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain., PMID:24220247
Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells., PMID:22526606
Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1)., PMID:21921034
Mapping of Ppp5c, the gene encoding protein phosphatase 5, to mouse chromosome 7., PMID:9196006
Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3., PMID:8666404
For research use only. Not for human or drug use.
