Catalog No.
YHH05001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly101-Gly358
Predicted molecular weight
31.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15257
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PP2A, subunit B', PR53 isoform, Serine/threonine-protein phosphatase 2A regulatory subunit 4, PPP2R4, PTPA, Serine/threonine-protein phosphatase 2A activator, Serine/threonine-protein phosphatase 2A regulatory subunit B', Phosphotyrosyl phosphatase activator
PTPA Governs Stress-Responsive Differentiation and Metabolic Homeostasis in Toxoplasma gondii., PMID:40498010
PTPA localized in the Golgi apparatus plays an important role in osteoblast differentiation., PMID:39827549
PtpA protein from Mycobacterium avium subsp. paratuberculosis as a potential marker of rheumatoid arthritis in humans., PMID:39752467
Human antibodies against Mycobacterium avium ssp. paratuberculosis combined with cytokine levels for the diagnosis and selection of Crohn's disease patients for anti-mycobacterial therapy-A pilot study., PMID:39365776
Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis infection., PMID:39175770
Endovascular Treatment for Peripheral Pulmonary Arterial Stenosis in RNF213-Related Vasculopathy., PMID:39074549
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs., PMID:38982062
PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation., PMID:38441530
Proteomic Analysis of Staphylococcus aureus Treated with ShangKeHuangShui., PMID:38281773
PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway., PMID:38279464
The secreted tyrosine phosphatase PtpA promotes Staphylococcus aureus survival in RAW 264.7 macrophages through decrease of the SUMOylation host response., PMID:37819153
Shikonin and Juglone Inhibit Mycobacterium tuberculosis Low-Molecular-Weight Protein Tyrosine Phosphatase a (Mt-PTPa)., PMID:37754203
ALA induces stomatal opening through regulation among PTPA, PP2AC, and SnRK2.6., PMID:37711306
Genomic Basis of Adaptive Divergence in Leg Length between Ground- and Tree-Dwelling Species within a Bird Family., PMID:37708414
Exploring the role of the protein tyrosine kinase a (PtkA) in mycobacterial intracellular survival., PMID:37657276
Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism., PMID:37424790
Application of codon usage and context analysis in genes up- or down-regulated in neurodegeneration and cancer to combat comorbidities., PMID:37383425
A Novel Aggregation-Induced Emission Fluorescent Probe for Detection of β-Amyloid Based on Pyridinyltriphenylamine and Quinoline-Malononitrile., PMID:37366974
Recombinant expression and preliminary characterization of Peptidyl-prolyl cis/trans-isomerase Rrd1 from Saccharomyces cerevisiae., PMID:37310980
Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH., PMID:37097752
Cross-Ethnic Variant Screening and Burden Analysis of PTPA in Parkinson's Disease., PMID:37046398
A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination., PMID:36932056
Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress., PMID:36589073
Bacterial Protein Tyrosine Phosphatases as Possible Targets for Antimicrobial Therapies in Response to Antibiotic Resistance., PMID:36552605
ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II., PMID:36463234
PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability., PMID:36073231
A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase-mediated tyrosine phosphorylation., PMID:35820485
Peptide PDHPS1 Inhibits Ovarian Cancer Growth through Disrupting YAP Signaling., PMID:35545004
Three Orphan Histidine Kinases Inhibit Clostridioides difficile Sporulation., PMID:35416689
Paladin, a tyrosine phosphatase-like protein, is required for XA21-mediated immunity in rice., PMID:34327325
PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition., PMID:34216687
Specific PP2A Catalytic Subunits Are a Prerequisite for Positive Growth Effects in Arabidopsis Co-Cultivated with Azospirillum brasilense and Pseudomonas simiae., PMID:33396893
"It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis., PMID:33194820
Post translational modifications in tuberculosis: ubiquitination paradox., PMID:33190592
Examining the levels of acetylation, DNA methylation and phosphorylation in HIV-1 positive and multidrug-resistant TB-HIV patients., PMID:33045438
Dipeptidyl-peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis., PMID:33006264
Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren., PMID:32979862
Characterization of a phosphotyrosyl phosphatase activator homologue of the parasitic nematode Haemonchus contortus and its immunomodulatory effect on goat peripheral blood mononuclear cells in vitro., PMID:32866490
Mycobacterium avium Subspecies paratuberculosis Infects and Replicates within Human Monocyte-Derived Dendritic Cells., PMID:32635236
Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A., PMID:32559055
Long-range replica exchange molecular dynamics guided drug repurposing against tyrosine kinase PtkA of Mycobacterium tuberculosis., PMID:32157138
Cornel Iridoid Glycoside Suppresses Tau Hyperphosphorylation and Aggregation in a Mouse Model of Tauopathy through Increasing Activity of PP2A., PMID:31902362
PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case-Control Study., PMID:31819587
Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A., PMID:31759088
Rapid serum tube technology overcomes problems associated with use of anticoagulants., PMID:31624459
ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra., PMID:31377193
UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology., PMID:31160454
Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma., PMID:30830869
Computational Approaches as Rational Decision Support Systems for Discovering Next-Generation Antitubercular Agents: Mini-Review., PMID:30706823
Distinct Mycobacterium marinum phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation, and escape to the cytosol., PMID:30656819
For research use only. Not for human or drug use.
