Catalog No.
YHK70701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu15-Ser181
Predicted molecular weight
21.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NWS0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nucleolar protein 17 homolog, PIH1D1, PIH1 domain-containing protein 1, NOP17
Molecular Signatures of Exercise Adaptation in Arabian Racing Horses: Transcriptomic Insights from Blood and Muscle., PMID:40282391
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP., PMID:40015274
The HSP90/R2TP Quaternary Chaperone Scaffolds Assembly of the TSC Complex., PMID:39490680
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling., PMID:38306274
Discriminating Potential Genetic Markers for Complete Response and Non-Complete Response Patients to Neoadjuvant Chemotherapy with Locally Advanced Rectal Cancer., PMID:35409691
The Expression of the RUVBL1 Component of the R2TP Complex Correlates with Poor Prognosis in DLBCL., PMID:35078195
Structure of the Human TELO2-TTI1-TTI2 Complex., PMID:34838521
Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes., PMID:34492227
Possible Protective Effect of LOXL1 Variant in the Cohort of Chernobyl Catastrophe Clean-Up Workers., PMID:34440405
Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone., PMID:34233195
RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes., PMID:32384603
Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM., PMID:31049401
Identification of RUVBL1 and RUVBL2 as Novel Cellular Interactors of the Ebola Virus Nucleoprotein., PMID:31018511
Advances on the Structure of the R2TP/Prefoldin-like Complex., PMID:30484153
How do our cells build their protein interactome?, PMID:30054485
Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex., PMID:30033218
The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones., PMID:29844425
Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly., PMID:29741156
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex., PMID:29662061
The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation., PMID:29203338
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex., PMID:28436950
A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression., PMID:26711270
Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly., PMID:26210662
Substrate recognition and function of the R2TP complex in response to cellular stress., PMID:25767478
The R2TP chaperone complex: its involvement in snoRNP assembly and tumorigenesis., PMID:25429602
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1., PMID:24794838
Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex., PMID:24656813
Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries., PMID:24394412
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription., PMID:24036451
RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival., PMID:23159623
Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis., PMID:22368283
PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis., PMID:21078300
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability., PMID:20864032
[Effect of PIH1D1 on the degradation of its binding protein SNF5]., PMID:20078948
For research use only. Not for human or drug use.
