Catalog No.
YHB01401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser37-Lys436
Predicted molecular weight
48.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60825
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, 6PF-2-K/Fru-2,6-P2ase heart-type isozyme, PFK/FBPase 2, PFKFB2, 6PF-2-K/Fru-2,6-P2ase 2
PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization., PMID:40502119
Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection., PMID:40481420
Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity., PMID:40402947
Spatial transcriptional landscape of human heart failure., PMID:40335066
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming., PMID:40000906
Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity., PMID:39763797
Circ_0008440 Inhibits Proliferation and Promotes Apoptosis of Trophoblast Cells through the miR-194-5p/PFKFB2 Axis., PMID:39663300
Hesperidin Suppressed Colorectal Cancer through Inhibition of Glycolysis., PMID:39581935
Mechanism of KMT2D-mediated epigenetic modification in IL-1β-induced nucleus pulposus cell degeneration., PMID:39380528
A susceptibility gene signature for ERBB2-driven mammary tumour development and metastasis in collaborative cross mice., PMID:39067134
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
M2 macrophages regulate KDM6B/PFKFB2 metabolic reprogramming of cervical squamous cell carcinoma through CXCL1., PMID:38836678
Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells., PMID:38813509
Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart., PMID:38533937
Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence., PMID:38455069
mTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells., PMID:38451470
The genetic and dietary landscape of the muscle insulin signalling network., PMID:38329473
Triptolide restrains the growth, invasion, stemness, and glycolysis of non-small cell lung cancer cells by PFKFB2-mediated PI3K/AKT pathway., PMID:38230789
HP promotes neutrophil inflammatory activation by regulating PFKFB2 in the glycolytic metabolism of sepsis., PMID:38227599
Epigenetic Profiling of Type 2 Diabetes Mellitus: An Epigenome-Wide Association Study of DNA Methylation in the Korean Genome and Epidemiology Study., PMID:38137029
AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth., PMID:38098117
The mitochondrial energy metabolism pathway-related signature predicts prognosis and indicates immune microenvironment infiltration in osteosarcoma., PMID:37986397
Formyl-peptide receptor 2 signalling triggers aerobic metabolism of glucose through Nox2-dependent modulation of pyruvate dehydrogenase activity., PMID:37875162
miR-21-5p inhibits the growth of brain glioma cells through regulating the glycolysis mediated by PFKFB2., PMID:37864733
Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study., PMID:37679740
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration., PMID:37541209
LC-MS/MS-Based Serum Metabolomics and Transcriptome Analyses for the Mechanism of Augmented Renal Clearance., PMID:37445637
PFKFB2 is a favorable prognostic biomarker for colorectal cancer by suppressing metastasis and tumor glycolysis., PMID:37311985
PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation., PMID:37155368
PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages., PMID:36797420
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney., PMID:36757995
BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy., PMID:36402789
Identification of the Transcriptional Biomarkers Panel Linked to Pathological Remodelling of the Eye Tissues in Various HD Mouse Models., PMID:35626712
Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2)., PMID:35184643
Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis., PMID:35059934
Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer., PMID:35027669
Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps., PMID:34282152
Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer., PMID:34109434
HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia., PMID:33678793
Major ceRNA regulation and key metabolic signature analysis of intervertebral disc degeneration., PMID:33676464
Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets., PMID:33671514
O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress., PMID:33651993
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models., PMID:33492659
miR-1297 Suppresses Osteosarcoma Proliferation and Aerobic Glycolysis by Regulating PFKFB2., PMID:33173315
CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2., PMID:32982406
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis., PMID:32884050
Integrated Genome-Wide Methylation and Expression Analyses Reveal Key Regulators in Osteosarcoma., PMID:32855654
Low glucose enhanced metformin's inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p., PMID:32718270
PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells., PMID:32415418
PP2Acα inhibits PFKFB2-induced glycolysis to promote termination of liver regeneration., PMID:32192773
For research use only. Not for human or drug use.
