Catalog No.
YHB24901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn126-Lys313
Predicted molecular weight
23.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75569
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PKR-associated protein X, Protein activator of the interferon-induced protein kinase, PACT, PRKRA, RAX, PKR-associating protein X, Interferon-inducible double-stranded RNA-dependent protein kinase activator A, Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Global translational regulation by Prkra: Is PKR no longer needed?, PMID:40378825
Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis., PMID:40349061
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency., PMID:40280134
Exome sequencing identifies novel genes associated with cerebellar volume and microstructure., PMID:40025133
Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade., PMID:39991958
Calcium release from damaged lysosomes triggers stress granule formation for cell survival., PMID:39962896
Genetic mutations in kinases: a comprehensive review on marketed inhibitors and unexplored targets in Parkinson's disease., PMID:39760821
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA., PMID:39512178
A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation., PMID:38895245
Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia., PMID:38837873
Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights., PMID:38458754
Large-Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes., PMID:38214203
Genetics and Pathogenesis of Dystonia., PMID:37738511
HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp., PMID:37710038
Exome-wide association study of treatment-resistant depression suggests novel treatment targets., PMID:37528149
Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response., PMID:37307272
Prkra Mutation Alters mRNA Expression During Embryonic External Ear Development., PMID:37185168
Mapping the landscape of genetic dependencies in chordoma., PMID:37024492
Antisense lncRNA CHROMR is linked to glioma patient survival., PMID:36950523
Luteolin protects DYT-PRKRA cells from apoptosis by suppressing PKR activation., PMID:36874028
Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis., PMID:36755464
Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes., PMID:36712121
Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq., PMID:36077333
PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation., PMID:35974143
Point Mutation in Prkra Alters miRNA Expression During Embryonic External Ear Development., PMID:35968958
Early-Onset Dystonia, Exacerbation With Fever, and Striatal Signal Changes: Emerging Phenotype of DYT-PRKRA., PMID:35914940
DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction., PMID:35625640
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c., PMID:35598827
Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank., PMID:35597955
Inhibiting the aberrant PACT-p53 axis activation ameliorates spinal cord ischaemia-reperfusion injury in rats., PMID:35421805
Identification of key genes and pathways at the downstream of S100PBP in pancreatic cancer cells by integrated bioinformatical analysis., PMID:35116411
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules., PMID:35075101
Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression., PMID:35035655
High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)., PMID:34520479
Tremor in Primary Monogenic Dystonia., PMID:34264428
Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation., PMID:34174402
Opposing forces fight over the same ground to regulate interferon signaling., PMID:34003254
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs., PMID:33911136
PRKRA-Related Disorders: Bilateral Striatal Degeneration in Addition to DYT16 Spectrum., PMID:33606314
Genotype-Phenotype Relations for Isolated Dystonia Genes: MDSGene Systematic Review., PMID:33502045
A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells., PMID:33479180
Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling., PMID:33459340
A pan-cancer atlas of somatic mutations in miRNA biogenesis genes., PMID:33406242
A tale of two proteins: PACT and PKR and their roles in inflammation., PMID:33387379
EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia., PMID:33236446
Combined dystonias: clinical and genetic updates., PMID:33099685
Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response., PMID:33049316
A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host., PMID:32631335
PACT/PRKRA and p53 regulate transcriptional activity of DMRT1., PMID:32251494
PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation., PMID:32175843
For research use only. Not for human or drug use.
