Catalog No.
YHK70301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg429
Predicted molecular weight
48.85 kDa
Nature
Recombinant
Concentration
0.17 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96P11
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Liquid
Storage buffer
PBS pH7.4, 0.02%NLS, 1mM EDTA
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NOL1R, NOL1-related protein, NSUN5, 28S rRNA (cytosine-C(5))-methyltransferase, WBSCR20A, NOL1/NOP2/Sun domain family member 5, WBSCR20, NSUN5A, Williams-Beuren syndrome chromosomal region 20A protein
Multi-Omics Analysis Unveils Nsun5-Mediated Molecular Alterations in the Somatosensory Cortex and Its Impact on Pain Sensation., PMID:40180179
NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization., PMID:40113612
Immunomodulatory Effects of SPHK1 and Its Interaction with TFAP2A in Yellow Drum (Nibea albiflora)., PMID:39769404
Diagnostic and predictive values of m5C‑associated genes in idiopathic pulmonary fibrosis., PMID:39704195
RNA Methyltransferase NSUN5 Promotes Esophageal Cancer via 5-Methylcytosine Modification of METTL1., PMID:39601515
NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression., PMID:39531371
NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer., PMID:39428025
Differentially localized protein identification for breast cancer based on deep learning in immunohistochemical images., PMID:39095659
Base-resolution m5C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach., PMID:39002544
Substrate diversity of NSUN enzymes and links of 5-methylcytosine to mRNA translation and turnover., PMID:38986569
The downregulation of NSUN5 may contribute to preeclampsia†., PMID:38924712
Exploration of the prognostic value of methylation regulators related to m5C in papillary thyroid carcinoma., PMID:38905403
NSUN6 mediates 5-methylcytosine modification of METTL3 and promotes colon adenocarcinoma progression., PMID:38800929
Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage., PMID:38712768
NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos., PMID:38670153
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion., PMID:38547058
RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism., PMID:38182896
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation., PMID:38065948
Niujiao Dihuang Jiedu decoction promotes SLC7A11 m5C methylation modification against ferroptosis in acute-on-chronic liver failure., PMID:38014838
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders., PMID:37905873
CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA., PMID:37845385
Identification and validation of key biomarkers based on RNA methylation genes in sepsis., PMID:37701433
NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth of Gastric Cancer Cells., PMID:37528314
NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression., PMID:37498063
m6A regulator-mediated RNA methylation modification remodels immune microenvironment in dilated cardiomyopathy., PMID:37475583
Knocking down NSUN5 inhibits the development of clear cell renal cell carcinoma by inhibiting the p53 pathway., PMID:37263638
Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma., PMID:37190010
RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma., PMID:37057706
Seven bacterial response-related genes are biomarkers for colon cancer., PMID:36941538
RNA-methyltransferase Nsun5 controls the maternal-to-zygotic transition by regulating maternal mRNA stability., PMID:36495115
NSUN5 promotes progression and predicts poor prognosis in hepatocellular carcinoma., PMID:36420066
Identification and validation of a novel signature as a diagnostic and prognostic biomarker in colorectal cancer., PMID:36319976
Transcriptional expression of m6A and m5C RNA methyltransferase genes in the brain and fat body of honey bee adult workers., PMID:36105348
The epitranscriptome in ageing and stress resistance: A systematic review., PMID:35908668
Prognostic Characteristics and Immune Effects of N6-Methyladenosine and 5-Methylcytosine-Related Regulatory Factors in Clear Cell Renal Cell Carcinoma., PMID:35571068
The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells., PMID:35249107
Novel insights into the role of 5-Methylcytosine RNA methylation in human abdominal aortic aneurysm., PMID:34856760
m5C RNA methyltransferase-related gene NSUN4 stimulates malignant progression of hepatocellular carcinoma and can be a prognostic marker., PMID:34744073
Proteomics-based prognostic signature and nomogram construction of hypoxia microenvironment on deteriorating glioblastoma (GBM) pathogenesis., PMID:34446747
Silver birch pollen-derived microRNAs promote NF-κB-mediated inflammation in human lung cells., PMID:34392209
The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans., PMID:33289480
Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma., PMID:33194076
NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor., PMID:33177158
High expression of NSUN5 promotes cell proliferation via cell cycle regulation in colorectal cancer., PMID:32774740
Exome sequencing identification of susceptibility genes in Chinese patients with keratoconus., PMID:32744102
Insights into the Regulatory Role of m6A Epitranscriptome in Glioblastoma., PMID:32316617
Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth., PMID:31722427
Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex., PMID:31462248
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program., PMID:31428936
Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase., PMID:31174389
For research use only. Not for human or drug use.
