Catalog No.
YHB05101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Gly85
Predicted molecular weight
22.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60936
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARC, Myp, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, NOL3, NOP, Nucleolar protein of 30 kDa, Nucleolar protein 3, Nop30
Nucleolar protein 3 promotes proliferation of bladder cancer cells through the PI3K-Akt pathway., PMID:39605067
Role of apoptosis repressor with caspase recruitment domain in human health and chronic diseases., PMID:39351758
FTO blocks RNA translational activity via the loss of N6-methyladenosine methylation at 5' UTR regulated by RBM5 in cisplatin-resistant NSCLC., PMID:38742685
TrkB-BDNF Signalling and Arc/Arg3.1 Immediate Early Genes in the Anterior Cingulate Cortex and Hippocampus: Insights into Novel Memory Milestones Through Behavioural Tagging., PMID:38485841
Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity., PMID:38166604
Complementary analysis of proteome-wide proteomics reveals changes in RNA binding protein-profiles during prostate cancer progression., PMID:37591798
Comparative Genomic Analysis Identifies Great-Ape-Specific Structural Variants and Their Evolutionary Relevance., PMID:37565562
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury., PMID:36652128
Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice-A Systematic Review., PMID:36361732
A novel signature model based on mitochondrial-related genes for predicting survival of colon adenocarcinoma., PMID:36273131
The Dysfunction of Carcinogenesis- and Apoptosis-Associated Genes that Develops in the Hypothalamus under Chronic Social Defeat Stress in Male Mice., PMID:36180995
Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays., PMID:35939377
Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis., PMID:35414011
Discovery and construction of prognostic model for clear cell renal cell carcinoma based on single-cell and bulk transcriptome analysis., PMID:34733651
Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice., PMID:34382577
Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes., PMID:33667344
Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin., PMID:33579312
Molecular Characterization and Clinical Relevance of RNA Binding Proteins in Colorectal Cancer., PMID:33193701
ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis., PMID:32816906
Apoptosis repressor with caspase recruitment domain promotes cell proliferation and phenotypic modulation through 14-3-3ε/YAP signaling in vascular smooth muscle cells., PMID:32771410
The synergistic antitumour effect of multi-components from Pulsatilla chinensis saponins in NCI-H460 lung cancer cell line through induction of apoptosis., PMID:32476531
Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart., PMID:32418060
Inhibition of microRNA-327 ameliorates ischemia/reperfusion injury-induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain., PMID:31587299
Reduced Hippocampal Neurogenesis in Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain (ARC)., PMID:31356897
Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease., PMID:31308798
Loss of nuclear ARC contributes to the development of cardiac hypertrophy in rats., PMID:31257698
Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling., PMID:30970510
ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening., PMID:30415165
Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review., PMID:29910734
Right ventricular involution: What can we learn from nature's model of compensated hypertrophy?, PMID:29370905
Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging., PMID:29274439
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging., PMID:29056555
Molecular basis for the effect of the L31F mutation on CARD function in ARC., PMID:28792591
Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro., PMID:28731195
Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation., PMID:28729244
The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling., PMID:28464919
A myeloid tumor suppressor role for NOL3., PMID:28232469
Elucidation of the genetic and epigenetic landscape alterations in RNA binding proteins in glioblastoma., PMID:28035070
Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment., PMID:27573706
Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro., PMID:27556499
Amygdala electrical stimulation inducing spatial memory recovery produces an increase of hippocampal bdnf and arc gene expression., PMID:27262671
Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways., PMID:27221790
REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype., PMID:27212034
Sequence-based analysis of 5'UTR and coding regions of CASP3 in terms of miRSNPs and SNPs in targetting miRNAs., PMID:27107179
Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53., PMID:26721253
The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth., PMID:26709830
Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels., PMID:26552011
Revealing Behavioral Learning Deficit Phenotypes Subsequent to In Utero Exposure to Benzo(a)pyrene., PMID:26420751
Erythropoietin Promotes Neural Plasticity and Spatial Memory Recovery in Fimbria-Fornix-Lesioned Rats., PMID:25847024
Crystallization and preliminary X-ray crystallographic analysis of the CARD domain of apoptosis repressor with CARD (ARC)., PMID:25615975
For research use only. Not for human or drug use.
