Catalog No.
YHD89001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr108-Gln496
Predicted molecular weight
47.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30419
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Myristoyl-CoA:protein N-myristoyltransferase 1, Type I N-myristoyltransferase, NMT 1, Peptide N-myristoyltransferase 1, NMT1, Glycylpeptide N-tetradecanoyltransferase 1, NMT
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover., PMID:40451428
Synthesis, characterization and bio-evaluation of novel series of pyrazoline derivatives as potential antifungal agents., PMID:40295598
Identification of NMT1/MA/VPS15 signal pathway as potential therapeutic target in rat cerebral ischemia injury., PMID:40221008
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein., PMID:39625987
An "In Schizo" Evaluation System to Screen for Human Kinesin-5 Inhibitors., PMID:39527212
Zelenirstat Inhibits N-Myristoyltransferases to Disrupt Src Family Kinase Signaling and Oxidative Phosphorylation, Killing Acute Myeloid Leukemia Cells., PMID:39382188
Cellular N-Myristoyl Transferases Are Required for Mammarenavirus Multiplication., PMID:39339839
An improved tetracycline-inducible expression system for fission yeast., PMID:39318285
Cellular N-myristoyl transferases Are Required for Mammarenavirus Multiplication., PMID:39211253
A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast., PMID:39105351
VP0 Myristoylation Is Essential for Senecavirus A Replication., PMID:39057827
A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas., PMID:38837078
Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition., PMID:38715059
Machine-learning prediction of a novel diagnostic model using mitochondria-related genes for patients with bladder cancer., PMID:38654047
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway., PMID:38409085
TNF-α-induced Inhibition of Protein Myristoylation Via Binding Between NMT1 and Sorbs2 in Osteoblasts., PMID:38148048
Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer., PMID:37905842
NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells., PMID:37269961
The role of N-myristoyltransferase 1 in tumour development., PMID:37140999
SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway., PMID:36967718
Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes., PMID:36873846
Establishment of a schizophrenia classifier based on peripheral blood signatures and investigation of pathogenic miRNA-mRNA regulation., PMID:36738648
Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression., PMID:36617552
The V2 Protein from the Geminivirus Tomato Yellow Leaf Curl Virus Largely Associates to the Endoplasmic Reticulum and Promotes the Accumulation of the Viral C4 Protein in a Silencing Suppression-Independent Manner., PMID:36560808
Hub Genes in Non-Small Cell Lung Cancer Regulatory Networks., PMID:36551208
The number of cytokinesis nodes in mitotic fission yeast scales with cell size., PMID:36093997
Reply to Comment on "Binding Affinity Determines Substrate Specificity and Enables Discovery of substrates for N-Myristoyltransferases"., PMID:35966602
RNA Polymerase II Transcription in Pneumocystis: TFIIB from Pneumocystis carinii Can Replace the Transcriptional Functions of Fission Yeast Schizosaccharomyces pombe TFIIB In Vivo and In Vitro., PMID:35743306
NMT1 Enhances the Stemness of NSCLC Cells by Activating the PI3K/AKT Pathway., PMID:35732157
Novel, First-in-Human, Oral PCLX-001 Treatment in a Patient with Relapsed Diffuse Large B-Cell Lymphoma., PMID:35323358
Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation., PMID:35205301
N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression., PMID:34999170
Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases., PMID:34956690
A Rapid Induction Overexpression System for the Fission Yeast Schizosaccharomyces pombe., PMID:34761070
Long noncoding RNA ANCR promotes migration, invasion, EMT progress and stemness of nasopharyngeal carcinoma cells via the miR-4731-5p/NMT1 axis., PMID:34333213
N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets., PMID:34136404
N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective., PMID:33916271
Nuclear localization of endothelial nitric oxide synthase and nitric oxide production attenuates aphidicolin-induced endothelial cell death., PMID:33592314
Reciprocal relation between reporter gene transcription and translation efficiency in fission yeast., PMID:33539828
N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target., PMID:33398478
A lncRNA-regulated gene expression system with rapid induction kinetics in the fission yeast Schizosaccharomyces pombe., PMID:32788323
N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells., PMID:32686708
A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation., PMID:32345632
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation., PMID:32111831
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle., PMID:32103017
Immunometabolism in the development of rheumatoid arthritis., PMID:31984519
Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening., PMID:31850752
Development of A Fission Yeast Cell-Based Platform for High Throughput Screening of HIV-1 Protease Inhibitors., PMID:31782368
Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses., PMID:31337802
Palladium based nanoparticles for the treatment of advanced melanoma., PMID:30824801
For research use only. Not for human or drug use.
