Catalog No.
YHB58801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly333-Thr611
Predicted molecular weight
35.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95251
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KAT7, HBOa, HBO1, MYST-2, MYST2, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, Histone acetyltransferase binding to ORC1, Histone acetyltransferase KAT7
Identification of Histone and N-Terminal Acetyltransferases Required for Reproduction and Embryonic Development of Yellow Fever Mosquito, Aedes aegypti., PMID:40235318
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression., PMID:40192836
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling., PMID:40186025
KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway., PMID:40084466
Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis., PMID:40064919
KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism., PMID:39984921
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway., PMID:39873724
Targeting KAT7 inhibits the progression of colorectal cancer., PMID:39816686
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions., PMID:39543485
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models., PMID:39321266
Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells., PMID:39258807
Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity., PMID:39009033
HBO1, a MYSTerious KAT and its links to cancer., PMID:38851533
KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma., PMID:38797155
Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function., PMID:38632351
KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer's disease., PMID:38617985
HBO1/KAT7/MYST2 HAT complex regulates human adenovirus replicative cycle., PMID:38601626
KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA., PMID:38593918
Guiding the HBO1 complex function through the JADE subunit., PMID:38448574
ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development., PMID:38446206
HBO1 determines SMAD action in pluripotency and mesendoderm specification., PMID:38421638
Histone lysine acetyltransferase inhibitors: an emerging class of drugs for cancer therapy., PMID:38383216
The ORFIUS complex regulates ORC2 localization at replication origins., PMID:38288445
MYST family histone acetyltransferases regulate reproductive diapause initiation., PMID:38029912
Bioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease., PMID:37993474
Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells., PMID:37779410
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia., PMID:37542030
Effect of sitagliptin on down-regulation of KAT7 and SIRT1 gene expression in breast cancer cell line MCF7., PMID:37433152
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma., PMID:37424170
Expression profiles and functional prediction of histone acetyltransferases of the MYST family in kidney renal clear cell carcinoma., PMID:37365518
The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver., PMID:37275850
The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy., PMID:37258203
The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke., PMID:37056143
Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression., PMID:36942752
KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer., PMID:36724120
A first-in-class HBO1 inhibitor WM-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo., PMID:36709328
Chromatin complex dependencies reveal targeting opportunities in leukemia., PMID:36707513
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7., PMID:36641753
Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation., PMID:36344675
A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia., PMID:36322781
BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease., PMID:36077605
KAT7 promoted gastric cancer progression through promoting YAP1 activation., PMID:35868058
HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth., PMID:35637972
Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7-acetylated and cytoplasm-translocated G protein GαS., PMID:35344606
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity., PMID:35266843
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance., PMID:35061506
The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal., PMID:34724565
The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis., PMID:34550360
Secretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species accumulation., PMID:34518516
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis., PMID:34431785
For research use only. Not for human or drug use.
