Catalog No.
YHK69901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp275-Ile505
Predicted molecular weight
28.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UNF1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Melanoma-associated antigen D2, BCG1, Hepatocellular carcinoma-associated protein JCL-1, MAGE-D2 antigen, MAGED2, 11B6, Breast cancer-associated gene 1 protein, BCG-1
MAGED2 Enhances Expression and Function of NCC at the Cell Surface via cAMP Signaling Under Hypoxia., PMID:39936967
X-linked transient antenatal Bartter syndrome related to MAGED2 gene: Enriching the phenotypic description and pathophysiologic investigation., PMID:39036894
Identification of a novel intronic mutation of MAGED2 gene in a Chinese family with antenatal Bartter syndrome., PMID:38238844
Successful antenatal treatment of MAGED2-related Bartter syndrome and review of treatment options and efficacy., PMID:38159268
Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer., PMID:38128647
Integrated single-cell and bulk RNA sequencing analysis identifies a neoadjuvant chemotherapy-related gene signature for predicting survival and therapy in breast cancer., PMID:37996875
MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway., PMID:37686237
Clinical Findings and Genetic Analysis of Nine Mexican Families with Bartter Syndrome., PMID:37516009
SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense., PMID:37439567
Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II., PMID:36359819
MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S., PMID:36010623
A novel MAGED2 variant in a Chinese preterm newborn with transient antenatal Bartter's syndrome with 4 years follow-up., PMID:34895150
MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells., PMID:34775100
Prenatal diagnosis of MAGED2 gene mutation causing transient antenatal Bartter syndrome., PMID:34400373
Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases., PMID:34307667
Establishment of a typing model for diffuse large B-cell lymphoma based on B-cell receptor repertoire sequencing., PMID:33752626
Pathophysiological aspects of the thick ascending limb and novel genetic defects: HELIX syndrome and transient antenatal Bartter syndrome., PMID:33733301
A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma., PMID:32941982
Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model., PMID:32739322
GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus., PMID:32580146
An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21., PMID:31653714
Prognostic roles of MAGE family members in breast cancer based on KM-Plotter Data., PMID:31516568
Serum levels of ANOS1 serve as a diagnostic biomarker of gastric cancer: a prospective multicenter observational study., PMID:31377880
[Genetic analysis of a pedigree affected with Bartter's syndrome]., PMID:31302915
Mimicry and well known genetic friends: molecular diagnosis in an Iranian cohort of suspected Bartter syndrome and proposition of an algorithm for clinical differential diagnosis., PMID:30760291
MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells., PMID:30541139
A step towards precision medicine in management of severe transient polyhydramnios: MAGED2 variant., PMID:29893154
MAGED2: a novel form of antenatal Bartter's syndrome., PMID:29677005
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response., PMID:29371029
Salt-Losing Tubulopathies in Children: What's New, What's Controversial?, PMID:29237739
Prevalence of Novel MAGED2 Mutations in Antenatal Bartter Syndrome., PMID:29146702
Pathophysiology of antenatal Bartter's syndrome., PMID:28598867
Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades., PMID:28516231
Nephrogenic diabetes insipidus., PMID:28134709
Future considerations based on the information from Barrter's and Gitelman's syndromes., PMID:27798456
MAGE-D2 and the Regulation of Renal Salt Transporters., PMID:27168439
Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations., PMID:27120771
Melanoma antigen-D2: A nucleolar protein undergoing delocalization during cell cycle and after cellular stress., PMID:26705694
The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression., PMID:25743330
Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression., PMID:25724522
Aberrant expression of melanoma-associated antigen-D2 serves as a prognostic indicator of hepatocellular carcinoma outcome following curative hepatectomy., PMID:25663882
The melanoma-associated antigen MAGE-D2 suppresses TRAIL receptor 2 and protects against TRAIL-induced apoptosis in human melanoma cells., PMID:22791814
Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer., PMID:20648585
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas., PMID:19383316
Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning., PMID:19197975
MAGED2: a novel p53-dissociator., PMID:17912449
Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed., PMID:16794389
The functional characterization of normal and neoplastic human enterochromaffin cells., PMID:16537680
Comparative proteomics of pulmonary tumors with neuroendocrine differentiation., PMID:16512680
Utility of molecular genetic signatures in the delineation of gastric neoplasia., PMID:16502410
For research use only. Not for human or drug use.
