Catalog No.
YHA02501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg223-Glu552
Predicted molecular weight
39.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00139
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KNS2, Kinesin-2, KIF2A, Kinesin-like protein KIF2A, hK2, KIF2
KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis., PMID:40353778
Crystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites., PMID:40302551
KIF2C is essential for meiosis and manchette dynamics in male mice., PMID:40213390
Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth., PMID:39930500
APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs., PMID:39640087
CtIP regulates G2/M transition and bipolar spindle assembly during mouse oocyte meiosis., PMID:39277031
Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability., PMID:39206808
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease., PMID:39168978
KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma., PMID:38974111
KIF2A Upregulates PI3K/AKT Signaling through Polo-like Kinase 1 (PLK1) to Affect the Proliferation and Apoptosis Levels of Eriocheir sinensis Spermatogenic Cells., PMID:38534420
Cytomorphological Disparities in Invasive Breast Cancer Cells following Neoadjuvant Endocrine Therapy and Chemotherapy., PMID:38447546
NuSAP regulates microtubule flux and Kif2A localization to ensure accurate chromosome congression., PMID:38117947
IGF2BP1 facilitates non-small cell lung cancer progression by regulating the KIF2A-mediated Wnt/β-catenin pathway., PMID:38102458
Multi-omics prognostic signatures of IPO11 mRNA expression and clinical outcomes in colorectal cancer using bioinformatics approaches., PMID:38028961
CAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis., PMID:37903275
Kinesin family member 2A gates nociception., PMID:37851573
Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5., PMID:37725512
The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules., PMID:37615667
Connecting neurodevelopment to neurodegeneration: a spotlight on the role of kinesin superfamily protein 2A (KIF2A)., PMID:37488893
The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network., PMID:37014312
Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis., PMID:36951681
RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling., PMID:36797232
Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons., PMID:36733270
Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling., PMID:36700049
HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells., PMID:36447525
Potential blood biomarkers for chronic traumatic encephalopathy: The multi-omics landscape of an observational cohort., PMID:36420308
Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly., PMID:36384111
KIF2A deficiency causes early-onset neurodegeneration., PMID:36343267
Circ_SATB2 knockdown inhibits the tumorigenesis of non-small cell lung cancer via miR-760/KIF2A axis., PMID:36196919
Circuit-wide proteomics profiling reveals brain region-specific protein signatures in the male WKY rats with endogenous depression., PMID:36162674
Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis., PMID:35949045
Genetic Control of Kinetochore-Driven Microtubule Growth in Drosophila Mitosis., PMID:35883570
Kinesin Family Member 2A Serves as a Potential Biomarker Reflecting More Frequent Lymph Node Metastasis and Tumor Recurrence Risk in Basal-Like Breast Cancer Patients., PMID:35784940
Aberrant kinesin family member 2A signifies tumor size and invasion, and may help predict prognosis of patients with papillary thyroid carcinoma., PMID:35765280
KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation., PMID:35718777
[Genetic and clinical analysis of KIF2A gene variant in a Chinese patient with complex cortical dysplasia and other brain malformations]., PMID:35315043
Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer., PMID:35313389
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) Was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma [Retraction]., PMID:35300058
The molecular mechanism of kinesin family member 2A (KIF2A) underlying non-small cell lung cancer: the effect of its knockdown on malignant behaviors, stemness, chemosensitivity, and potential regulated signaling pathways., PMID:35173830
Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer., PMID:35164763
Mechanism of miR-424-5p promoter methylation in promoting epithelial-mesenchymal transition of hepatocellular carcinoma cells., PMID:35049148
Calcium-Mediated Calpain Activation and Microtubule Dissociation in Cell Model of Hereditary Sensory Neuropathy Type-1 Expressing V144D SPTLC1 Mutation., PMID:34986032
NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation., PMID:34887424
Kinesin family member 2A acts as a potential prognostic marker and treatment target via interaction with PI3K/AKT and RhoA/ROCK pathways in acute myeloid leukemia., PMID:34792179
Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs., PMID:34738156
The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain., PMID:34582949
Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis., PMID:34417301
Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish., PMID:34404749
Mechanical Stimulation after Centrifuge-Free Nano-Electroporative Transfection Is Efficient and Maintains Long-Term T Cell Functionalities., PMID:34396686
SCFFbxw5 targets kinesin-13 proteins to facilitate ciliogenesis., PMID:34368969
For research use only. Not for human or drug use.
