Catalog No.
YHA39501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro1186-Arg1643
Predicted molecular weight
54.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15054
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
JMJD3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B, Jumonji domain-containing protein 3, KDM6B, JmjC domain-containing protein 3, KIAA0346, Lysine demethylase 6B, Lysine-specific demethylase 6B
H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases., PMID:40503225
Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA., PMID:40460907
The writing on the arterial wall: epigenetic control of blood pressure and vascular remodeling., PMID:40454472
KDM6B is a conserved activator at the top of the male sex determination pathway., PMID:40406982
Fusobacterium mortiferum and its metabolite 5-aminovaleric acid promote the development of colorectal cancer in obese individuals through Wnt/β-catenin pathway by DKK2., PMID:40340623
Epigenetic mechanism of iPSC-MSC-EVs in colonic epithelial cell pyroptosis in ulcerative colitis cell models via modulation of ELF3/miR-342-3p/KDM6B axis and histone methylation., PMID:40315630
NF-κB-mediated enhancement of H3K27me3 through EZH2: a mechanism to suppress pyocyanin-induced autophagy in macrophages., PMID:40301947
Impact of fish oil on epigenetic regulation in perirenal adipose tissue of obese mice., PMID:40246605
Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling., PMID:40146226
Histone demethylase KDM6B promotes glioma cell proliferation by increasing PDGFRA expression via chromatin loop formation., PMID:40134212
High-dose estrogen impairs demethylation of H3K27me3 by decreasing Kdm6b expression during ovarian hyperstimulation in mice., PMID:40082205
The Histone Demethylase Inhibitor GSK-J4 Attenuates Periodontal Bone Loss and Inflammation in a Rat Model of Periodontitis., PMID:40048054
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes., PMID:39969745
Identification of novel autoantibodies in Sjögren's disease., PMID:39963128
KDM6B preferentially promotes bone formation over resorption to facilitate postnatal bone mass accrual through collagen triple helix repeat containing 1-mediated PKCδ/MAPKs signaling., PMID:39961019
Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration., PMID:39951327
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis., PMID:39862918
KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice., PMID:39842437
Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia., PMID:39813767
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis., PMID:39800682
The histone demethylase KDM6B links obstructive sleep apnea to idiopathic pulmonary fibrosis., PMID:39781582
Genetic Heterogeneity in Four Probands Reveals HGSNAT, KDM6B, LMNA and WFS1 Related Neurodevelopmental Disorders., PMID:39767643
Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis., PMID:39745222
Depletion of MicroRNA-100-5p Promotes Osteogenesis Via Lysine(K)-Specific Demethylase 6B., PMID:39718900
JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain., PMID:39716224
Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells., PMID:39680456
KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression., PMID:39603516
Transcriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery., PMID:39585493
AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop., PMID:39548506
Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying Circ-Tulp4 Attenuate Diabetes Mellitus with Nonalcoholic Fatty Liver Disease by Inhibiting Cell Pyroptosis through the HNRNPC/ABHD6 Axis., PMID:39546192
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B., PMID:39483904
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B., PMID:39482699
[Effect of JMJD3-IRF4 Signaling Pathway-Mediated Macrophage Polarization on the Malignant Biological Behavior of Multiple Myeloma Cells]., PMID:39479832
Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer., PMID:39426954
Enriched H3K27Me3 on BMP4 suppresses the osteoblastic differentiation potential of BMSCs in diabetes mellitus., PMID:39401480
Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma., PMID:39392932
Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy., PMID:39337533
A high proportion of germline variants in pediatric chronic myeloid leukemia., PMID:39327604
Intervention of inflammation associated with ankylosing spondylitis by triptolide promotes histone H3 Iys-27 trimethylation., PMID:39307916
Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7., PMID:39276004
α-Ketoglutarate promotes cardiomyocyte proliferation and heart regeneration after myocardial infarction., PMID:39223390
Impact of KDM6B mosaic brain knockout on synaptic function and behavior., PMID:39223259
Curcumenol regulates Histone H3K27me3 demethylases KDM6B affecting Succinic acid metabolism to alleviate cartilage degeneration in knee osteoarthritis., PMID:39126921
A Novel Role for the Histone Demethylase JMJD3 in Mediating Heroin-Induced Relapse-Like Behaviors., PMID:39019389
[H3K27me3 Expression Level and Its Epigenetic Regulation Mechanisms in Th17 Cell Differentiation in Patients With Ankylosing Spondylitis]., PMID:38948276
Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling., PMID:38869447
High-intensity interval training ameliorates postnatal immune activation-induced mood disorders through KDM6B-regulated glial activation., PMID:38851307
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation., PMID:38842922
M2 macrophages regulate KDM6B/PFKFB2 metabolic reprogramming of cervical squamous cell carcinoma through CXCL1., PMID:38836678
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice., PMID:38795338
For research use only. Not for human or drug use.
